CELL RES: Wuda Bell Wave team finds ubiquitin-regulating antiviral response and autoimmune
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Last Update: 2020-05-29
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Source: Internet
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Author: User
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Ring-like GMP-AMP synthase (cGAS) is an important sensor of cytoplasm DNA and plays an important role in congenital immune response and autoimmuneRegulating the activity and stability of cGAS provides a potential strategy for the treatment of viral or autoimmune diseasesrecently, researchers have found that ubiquitin-specific protease 29 (USP29) demutants and stabilizes cGAS, promoting cellular antiviral response and autoimmuneThe low or knock-down of USP29 seriously damaged the expression of herpes simplex virus 1 (HSV-1) - or intracellular DNA-induced type I interferon (IFNs) and inflammatory cytokinesconsistent, Usp29m/m mice produced a reduction in type I IFNs and pro-inflammatory cytokines after HSV-1 infection and were more sensitive to HSV-1 infection than wild micein addition, in Trex1-/-mice, the USP29 gene knockout eliminates detectable pathological and molecular autoimmune phenotypesthe mechanism, USP29 interacts with cGAS to disengage the polyuclusive chain of cGAS and K48 connected and stabilizes cGAS in uninfected cells or after HSV-1 infectionRecombining cGAS into Usp29-/-cells can completely save the induction of type I IFN and the antiviral response of cells after HSV-1 infectiontherefore, the results reveal the key role of USP29 in the congenital antiviral response to DNA viruses and autoimmune diseases, and provide a revelation for the regulation of cGAS
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