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    Home > Biochemistry News > Biotechnology News > Cell Research: Fetal Liver Hematopoietic Stem Cell Expansion Function Unit "HSC PLUS"

    Cell Research: Fetal Liver Hematopoietic Stem Cell Expansion Function Unit "HSC PLUS"

    • Last Update: 2021-08-15
    • Source: Internet
    • Author: User
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    As a river of life, blood continuously provides nutrients and immune protection for the body

    August 2, 2021, College of Life Sciences, Peking University team and Lee Cheng Liu Feng Institute of Zoology, Chinese Academy of team cooperation in Cell Research magazine entitled Identification HSC / MPP expansion units in fetal liver by single-cell spatiotemporal transcriptomics of research Thesis

    First, the researchers used single-cell transcriptome sequencing technology to draw a transcriptome map of the development of fetal liver blood cells and microenvironmental cells, and analyze the dynamic changes of the transcriptome of hematopoietic stem/progenitor cells and microenvironmental cells

    In order to verify the spatial relationship between interacting cells and paired signaling molecules, the researchers mapped the spatial transcriptome of the fetal liver

    Finally, by comparing and analyzing the published single-cell transcriptome data of mouse fetal liver and human fetal liver, the researchers found that there are also conservative amplification structures and molecular mechanisms in human fetal liver

    In summary, this study draws the single-cell spatiotemporal transcriptome map of mouse fetal liver development for the first time, and identifies the functional unit of hematopoietic tissue (HSC PLUS), which not only deepens our understanding of the expansion of hematopoietic stem cells in vivo, but also expands Our understanding of tissue functional units also provides more clues for the expansion of hematopoietic stem cells in vitro

    Researcher Liu Feng from the Institute of Zoology, Chinese Academy of Sciences and researcher Li Cheng from the School of Life Sciences, Peking University are the co-corresponding authors of this article

    Schematic diagram of fetal liver hematopoietic stem cell expansion functional unit

    Article link: https://






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