Cell Research of Fudan University Academy of Sciences publishes: Lipid-lowering compounds targeting autophagy (LD-ATTEC)

Many diseases are caused by the accumulation of specific biological macromolecules, and the specific degradation of these pathogenic molecules can fundamentally intervene or treat diseases.

On July 8th, Lu Boxun from the School of Life Sciences of Fudan University and Ding Fu's research group published an article "Degradation of lipid droplets using autophagosome-binding compounds" in the journal Cell Research.

The realization of this goal is based on the original ATTEC (AuTophagy-TEthering Compounds) technology published in 2019 by the team of Lu Boxun/Fei Yiyan/Ding Fu of Fudan University

The project team designed the ATTEC compound (LD-ATTEC) with lipid droplets, an organelle that stores fat in cells, as the degradation target

This research conceptually proves that the assembled splicing ATTEC can directly and specifically target non-protein biological substances to the autophagy-lysosomal pathway for degradation, and realizes the targeted degradation technology of non-protein substances for the first time, and proves The assembly-connected ATTEC concept opens up a possible original path for new drug research and development

Fu Yuhua, a young associate researcher at Fudan University, the first author of this article, PhD students Chen Ningxie and Wang Ziying, and Plymouth University professor Luo Shouqing also participated in this research.

Link to the paper: https://