Cell Research reveals the functional unit "HSC PLUS" for fetal liver hematopoietic stem cell expansion

As a river of life, blood continuously provides nutrients and immune protection for the body

August 2, 2021, the team, and Liu Feng of Peking University Institute of Zoology, Chinese Academy of Sciences Institute of Life Sciences, Li Cheng team published in Cell Research magazine entitled Identification HSC / MPP expansion units in fetal liver by single-cell spatiotemporal transcriptomics of research Thesis

First, the researchers used single-cell transcriptome sequencing technology to draw a transcriptome map of the development of fetal liver blood cells and microenvironmental cells, and analyze the dynamic changes of the transcriptome of hematopoietic stem/progenitor cells and microenvironmental cells

In summary, this study draws the single-cell spatiotemporal transcriptome map of mouse fetal liver development for the first time, and identifies the functional unit of hematopoietic tissue (HSC PLUS), which not only deepens our understanding of the expansion of hematopoietic stem cells in vivo, but also expands Our understanding of tissue functional units also provides more clues for the expansion of hematopoietic stem cells in vitro

Schematic diagram of fetal liver hematopoietic stem cell expansion functional unit

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