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June 30, 2021 News/Bio Valley BIOON/---The choroid plexus (choroid plexus) was once only regarded as the producer of the cerebrospinal fluid (CSF) that bathes the brain and spinal cord.
Dr.
Extract choroid plexus tissue
Isolating choroid plexus tissue from embryos, adult, and old mice is a job in itself
With choroid plexus tissue from the three ventricles of mice, the authors performed RNA sequencing on more than 98,000 cells and nuclei to compare their gene expression profiles (which genes are on or off)
Lehtinen said, “We have done bulk RNA sequencing on choroid plexus tissue before, but it’s like putting everything in a blender
Choroid plexus cell bank
These authors found that the unique choroid plexus organization of each ventricle has a complex "architecture
In addition to core cell types, these authors also discovered several neuronal subtypes
These sequencing data also revealed differences in cell secretions and molecular makeup
Protect the brain
These authors found a large amount of immune activity in the choroid plexus, where several types of immune cells reside, the most common being macrophages
The picture is from Cell, 2021, doi:10.
Lehtinen said, "We can now begin to analyze how different immune cell populations are activated and how they respond to injury
Other findings show the arrangement of arteries, veins, and capillaries in the choroid plexus, and their structural relationship with adjacent brain regions
A treatment "window"?
With this resource, the scientific community now has a lot to explore
Lehtinen said, "Gene therapy for CSF and choroid plexus may be an exciting treatment
In other research work, Lehtinen and colleagues recently discovered that before birth, the choroid plexus can become a pathway for inflammation caused by maternal infections, paving the way for the study of neurodevelopmental diseases such as autism
Reference materials:
Reference materials:Neil Dani et al.