Cell reveals that patients with COVID-19 asymptomatic or recovery periods have strong resistance.

As of August 17, 2020, the new coronavirus (SARS-CoV-2) has had a huge impact on the world, with 21.59 million confirmed cases and 770,000 deaths of the new coronavirus pneumonia (new coronary pneumonia, COVID-19).
, however, some patients were only slightly affected during COVID-19, with asymptomatic or mild symptoms.
August 14, 2020, researchers at the Center for Infectious Disease Medicine at Karolinska Medical College in Sweden published a research paper entitled Robust T cell immunity in convalescent individual withasymptomatic or mild COVID-19 online. D-19 acute SARS-CoV-2 specific T cells exhibit active cytotoxic esotoxic esotoxicity, a wide range of multi-functional T-cell reactions during recovery, and SARS-CoV-2 specific T-cell reactions are also detected in serum-negative individuals.
previous studies have shown that SARS-CoV-2 infections in rhesus monkeys protect them from secondary attacks, according to previous studies of DOI:10.1016/j.cell.2020.08.017.
, there are relatively few cases of re-infection in patients with neo-crown pneumonia.
to assess the durability of the protective immune response caused by sars-CoV-2 initial infection, the researchers recruited 206 patients with varying degrees of new coronary pneumonia to study their CD4-plus, CD8-T cells.
the results showed that the level of CD4 plus and CD8 plus T cells in patients with acute moderate and severe neocytic pneumonia was low.
PCA analysis showed that there was a significant separation between memory T cells in patients with acute moderate and severe neo-coronary pneumonia and memory T cells in recovery patients and healthy controls, mainly in CD38, CD69, Ki-67 in CD4-T cells. and PD-1 expressions, as well as CD38, CD39, CD69, CTLA-4, HLA-DR, Ki-67, LAG-3, and TIM-3 in CD8-T cells.
high expression of memory CD4-T and CD8-T cells associated with activation and cell cycles in patients with acute, moderate and severe neocytic pneumonia.
correlation analysis showed that the expression of markers associated with activation and cell cycle was closely related to SARS-CoV-2 IgG levels and various clinical parameters.
results show that the early COVID-19 body has a strong SARS-COV-2 specific immune response.
further analysis of early T-cell disorders in neo-coronary pneumonia, the researchers found that the expression of CCR7 and CD45RA was positively associated with the number of asymptomatic days after infection in patients with acute moderate and severe neocytocytes with high expression CD38, and in SARS-CoV-2 specific CD8-T cells, the expression of CCR7 and CD45RA was positively associated with the number of asymptomatic days after infection.
Then, the researchers quantified functional SARS-CoV2-specific memory T-cell responses in different cohorts, including healthy controls of blood taken before the pandemic, family members of patients with neo-coronary pneumonia, and patients in the recovery phase after mild and severe infection with neo-corona pneumonia.
study found that patients during the recovery period of neocoopnea showed T-cell reactions to SARS-CoV2 ratchet protein, membrane protein, and nuclear crust protein.
SARS-CoV-2-specific CD4-T cells mainly express IFN-T, IL-2, and TNF, while SARS-CoV-2-specific CD8-T cells mainly express IFN-T cells.
interesting is that ratchet-specific CD4-T cells polarize T-filter-assisted cells, while membrane-specific and nuclear-shell-specific CD4-T cells polarize to Th1 or Th1/Th17.
the last functional characteristics of SARS-CoV-2-specific T cells during the recovery period, the researchers found that most recovery patients and exposed family members were able to detect memory CD4 plus and CD8 plus T cells.
serological evaluation showed a highly positive correlation between immunoglobulin response to SARS-CoV2 ratchet protein and immunoglobulin response to SARS-CoV2 nuclear shell protein.
family members also responded more to T-cells than unexposed healthy controls.
, the body can stimulate a powerful memory T-cell response without or in the presence of circulating antibodies.
in summary, the study system analyzed the function and spectral map of SARS-CoV-2 specific T-cell immunity throughout the exposure, infection and disease recovery phase, and found that many patients with asymptomatic or mild neo-coronary pneumonia developed a highly persistent and functional memory T-cell response after exposure or infection with SARS-CoV-2, and natural exposure or infection prevented the recurrence of severe neo-coronary pneumonia.
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