Cell: Seize the cancer 'metabolic weakness'! Real-time metabolic tracking and fat-free diet, good efficacy of tumor diagnosis and treatment

Often, cancer cells rely heavily on breaking down fat to promote their own growth and spreadA new study has found that surgical "iKnife" can capture this weakness of cancer cells, and then use a combination of new drugs and dietary controls to achieve a new model ofdiagnosistreatmentthe study was published in the journal Cell by the team of the Zoltan Takats team at Imperial College London and George Poulogiannis, inventor of iKnife Smart Knifefive years ago, Professor Zolta Takats invented the smart scalpel iKnife, which uses charge to burn cancerous tissue, extract information from the gas emitted by tissue combustion, and feed it back to surgeons, helpdoctoring to accurately remove cancerous tissue, reduce damage to cancerous tissue and reduce the risk of postoperative tumor regenerationThe combination of iKnife with rapid evaporation ionization mass spectrometry (REIMS) enables instantaneous chemical analysis of aerosols produced during tissue burningspecifically, in the latest study, scientists studied cancer cells and patient-derived tumors in the lab through iKnife to look for "metabolic fingerprints" and later discovered a molecule called PI3K, which is critical to the growth and survival of cancer cells and plays a key role in triggering the release of peanut tetraoleic acid, a key omega-6 fatresearchers found that the mutation form of PI3K (PIK3CA) drives multiple signaling pathways, which involve the activation of another key molecule, cPLA2, which releases peanut tetraoleic acid, which in turn contributes to uncontrolled growth and spread of cancerThe team later showed in mouse studies that a new drug called cPLA2 inhibitors, which is used in clinical trials to treat various inflammatory diseases, could be used to treat fat-dependent cancersBut these drugs are only effective if combined with dietary changes to limit fat intakebecause tumors with the mutant PI3K stopped growing and spreading when mice were treated with cPLA2-suppressing drugs and fed a plant-based fat-free diet at the same timeHowever, cPLA2 inhibitors were ineffective when mice were fed a "western" diet rich in omega-6 fatty acidsresearchers concluded that targeting cPLA2 is only effective when peanut tetraoleic acid or other fats without a dietary source contribute to cancerIn other words, for these drugs to be effective, a fat-free plant diet must be adoptedof course, they stress that these findings apply only to the use of these experimental cPLA2 inhibitors, not that the presence of fat interferes with any existing anti-cancer drugs, or that fat restrictioninin in the diet stops tumor growthWe've known for a long time that cancer has genetic weaknesses that can be treated, but our research shows that cancer salsos with specific metabolic weaknesses"We found that tumors often rely heavily on specific fats and their products to promote their growth and spread, and the ability to stop them from processing them may be an effective treatment," says DrGeorge PoulogiannisProfessor Paul Workman, director of the Cancer Institute in London,, said: "This is an exciting and important study that suggests that cancer can be understood and treated by looking at so-called metabolic fingerprint mapsThe new findings identify specific metabolic weaknesses in cancer cells that can be used in combination with a fat-free diet through innovative drugs;summary, this study suggests that preventing a particular cancer subtype from releasing a key omega-6 fat called peanut tetraoleic acid may be an effective treatment, but only if the source of the fat in the diet is also eliminatedIn addition, analyzing metabolic fingerprints of cancer is a key tool for understanding, diagnosing and treating the diseaseIn the future, it may be possible to analyze the metabolic fingerprints of cancer when patients use iKnife's operating table, and combine them with medications and dietary therapies