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Stem cell transplantation does not cause changes in the DNA of the donor cells
Stem cell transplantation is an important part of treating some children with leukemia
The safety of transplantation
Researchers from Van Boxtel's team at Princess Maxima Children's Cancer Center studied the entire DNA of blood stem cells from nine patients who had received stem cell transplants
They found that most transplanted blood stem cells did not contain more mutations than healthy donors
The research was published in the journal Cell Stem Cell and was supported by funders such as NWO and the European Research Council
Unknown "scar" in DNA
In a small number of patients, the Van Boxtel team, also affiliated with the Oncode Institute, discovered specific DNA mutation patterns or "scars" that they had never seen before
In this way, the scientists found nine more patients with this DNA scar in their cancer
Cancer gene mutation
To study whether ganciclovir actually caused DNA changes, the research team exposed cultured blood stem cells to ganciclovir in the laboratory
The team then tested another antiviral drug: foscarnet, which is also used to treat viral infections after stem cell transplantation, but due to the side effects on the kidneys, most patients cannot tolerate it for a long time
In order to better understand the effects of ganciclovir on DNA, longer-term further studies are now needed in a larger patient population
"Thanks to new technologies that uncover the entire genetic makeup of tumors, we have discovered that an antiviral drug may have carcinogenic effects
"The exact effect of ganciclovir on the scars left by the DNA is still unclear
"There are currently more than 30 antiviral drugs of this type on the market that are used to combat various viral infections
The author said, "It is gratifying that stem cell transplantation is a method of treating children and adults with leukemia and other blood diseases.
"Thanks to this research, we now know that ganciclovir treatment after stem cell transplantation may have long-term side effects in some patients
"Viral infections after stem cell transplantation can be serious and sometimes life-threatening
Original search:
DOI10.
1016 / j.
stem.
2021.
07.
012
Antiviral treatment causes a unique mutational signature in cancers of transplantation recipients
