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March 8, 2021 //---Researchers at UT Southwestern University and Indiana University used genetic engineering techniques to reprogram the scar-forming cells in the mouse spinal cord to generate new nerve cells, which stimulated Recovery after spinal cord injury.
The discovery, published online today in the journal Cell Stem Cell, can provide hope for hundreds of thousands of people who suffer spinal cord injury every year around the world.
The discovery, published online today in the journal Cell Stem Cell, can provide hope for hundreds of thousands of people who suffer spinal cord injury every year around the world.
(Image source:style="font-size: 9pt;">(Image source:style="text-align: justify;">Cells in certain body tissues will proliferate after injury, and as part of the healing process, it will replace dead or damaged cells.
However, the research leader, Professor Chunli Zhang of Northwestern University in the United States, explained that research shows that the spinal cord usually does not produce new neurons after injury, which is a key obstacle to recovery.
He added that because the spinal cord is a signal relay between the brain and the rest of the body, its inability to repair itself will permanently interrupt the communication between these two areas, leading to paralysis, loss of sensation, and sometimes even life-threatening.
For example, the inability to control breathing or heart rhythm.
However, the research leader, Professor Chunli Zhang of Northwestern University in the United States, explained that research shows that the spinal cord usually does not produce new neurons after injury, which is a key obstacle to recovery.
He added that because the spinal cord is a signal relay between the brain and the rest of the body, its inability to repair itself will permanently interrupt the communication between these two areas, leading to paralysis, loss of sensation, and sometimes even life-threatening.
For example, the inability to control breathing or heart rhythm.
Zhang pointed out that the brain relies on progenitor cells to initiate different regeneration pathways, so the ability to generate new nerve cells is limited.
Inspired by this knowledge, he and his colleagues searched for cells with similar regenerative potential in the spinal cord.
Inspired by this knowledge, he and his colleagues searched for cells with similar regenerative potential in the spinal cord.
The researchers used mouse spinal cord injury models to search for markers normally found in immature neurons in the injured spinal cord of animals.
The authors not only found this marker in the spinal cord after injury, but also tracked the cells that produced it: non-neuronal cells called NG2 glial cells.
The authors not only found this marker in the spinal cord after injury, but also tracked the cells that produced it: non-neuronal cells called NG2 glial cells.
NG2 glial cells are the progenitor cells of oligodendrocytes, and oligodendrocytes produce an insulating fat layer surrounding neurons.
As we all know, they form colloidal scars after being injured.
Zhang's team showed that when the spinal cord is injured, these glial cells temporarily adopt the molecular and morphological markers of immature neurons.
As we all know, they form colloidal scars after being injured.
Zhang's team showed that when the spinal cord is injured, these glial cells temporarily adopt the molecular and morphological markers of immature neurons.
In order to determine the cause of the changes in NG2 glial cells, the researchers focused on SOX2 (a stem cell protein induced by damage).
They genetically manipulated these cells to inactivate the gene that makes the protein.
After severing the spinal cord of the manipulated mouse, the researchers saw far fewer immature neurons in the days after the injury, indicating that SOX2 plays a key role in helping NG2 glial cells make these cells.
.
However, even if SOX2 levels are normal, these immature neurons will never mature to replace the damaged neurons.
They genetically manipulated these cells to inactivate the gene that makes the protein.
After severing the spinal cord of the manipulated mouse, the researchers saw far fewer immature neurons in the days after the injury, indicating that SOX2 plays a key role in helping NG2 glial cells make these cells.
.
However, even if SOX2 levels are normal, these immature neurons will never mature to replace the damaged neurons.
Instead, Zhang and his colleagues used another genetic manipulation technique to overproduce SOX2 in NG2 glial cells.
Excitingly, within a few weeks after spinal cord injury, the mice undergoing this manipulation produced tens of thousands of new mature neurons.
Further research has shown that these neurons are integrated into the injured area and establish new connections with existing neurons, which are necessary for the transmission of signals between the brain and the body.
Excitingly, within a few weeks after spinal cord injury, the mice undergoing this manipulation produced tens of thousands of new mature neurons.
Further research has shown that these neurons are integrated into the injured area and establish new connections with existing neurons, which are necessary for the transmission of signals between the brain and the body.
More hopefully, this genetic engineering has led to improved function after spinal cord injury.
Animals engineered to overproduce SOX2 in NG2 glial cells have significantly better motor skills in the weeks after spinal cord injury than animals that produce normal SOX2
Animals engineered to overproduce SOX2 in NG2 glial cells have significantly better motor skills in the weeks after spinal cord injury than animals that produce normal SOX2
In the end, researchers may be able to find a safe and effective way to overproduce SOX2 in human spinal cord injury patients, thereby helping them repair the damage with new neurons while reducing the formation of scar tissue.
(Bioon.
com)
(Bioon.
com)
Information source: com/news/2021-03-protein-overdrive-spinal-cord-injuries.
html">Putting a protein into overdrive to heal spinal cord injuries
html">Putting a protein into overdrive to heal spinal cord injuries
Original source: Cell Stem Cell (2021).
dx.
doi.
org/10.
1016/j.
stem.
2021.
02.
009
dx.
doi.
org/10.
1016/j.
stem.
2021.
02.
009
Zhang pointed out that the brain relies on progenitor cells to initiate different regeneration pathways, so the ability to generate new nerve cells is limited.
Inspired by this knowledge, he and his colleagues searched for cells with similar regenerative potential in the spinal cord.
Inspired by this knowledge, he and his colleagues searched for cells with similar regenerative potential in the spinal cord.
The researchers used mouse spinal cord injury models to search for markers normally found in immature neurons in the injured spinal cord of animals.
The authors not only found this marker in the spinal cord after injury, but also tracked the cells that produced it: non-neuronal cells called NG2 glial cells.
The authors not only found this marker in the spinal cord after injury, but also tracked the cells that produced it: non-neuronal cells called NG2 glial cells.
NG2 glial cells are the progenitor cells of oligodendrocytes, and oligodendrocytes produce an insulating fat layer surrounding neurons.
As we all know, they form colloidal scars after being injured.
Zhang's team showed that when the spinal cord is injured, these glial cells temporarily adopt the molecular and morphological markers of immature neurons.
As we all know, they form colloidal scars after being injured.
Zhang's team showed that when the spinal cord is injured, these glial cells temporarily adopt the molecular and morphological markers of immature neurons.
In order to determine the cause of the changes in NG2 glial cells, the researchers focused on SOX2 (a stem cell protein induced by damage).
They genetically manipulated these cells to inactivate the gene that makes the protein.
After severing the spinal cord of the manipulated mouse, the researchers saw far fewer immature neurons in the days after the injury, indicating that SOX2 plays a key role in helping NG2 glial cells make these cells.
.
However, even if SOX2 levels are normal, these immature neurons will never mature to replace the damaged neurons.
They genetically manipulated these cells to inactivate the gene that makes the protein.
After severing the spinal cord of the manipulated mouse, the researchers saw far fewer immature neurons in the days after the injury, indicating that SOX2 plays a key role in helping NG2 glial cells make these cells.
.
However, even if SOX2 levels are normal, these immature neurons will never mature to replace the damaged neurons.
Instead, Zhang and his colleagues used another genetic manipulation technique to overproduce SOX2 in NG2 glial cells.
Excitingly, within a few weeks after spinal cord injury, the mice undergoing this manipulation produced tens of thousands of new mature neurons.
Further research has shown that these neurons are integrated into the injured area and establish new connections with existing neurons, which are necessary for the transmission of signals between the brain and the body.
Excitingly, within a few weeks after spinal cord injury, the mice undergoing this manipulation produced tens of thousands of new mature neurons.
Further research has shown that these neurons are integrated into the injured area and establish new connections with existing neurons, which are necessary for the transmission of signals between the brain and the body.
More hopefully, this genetic engineering has led to improved function after spinal cord injury.
Animals engineered to overproduce SOX2 in NG2 glial cells have significantly better motor skills in the weeks after spinal cord injury than animals that produce normal SOX2
Animals engineered to overproduce SOX2 in NG2 glial cells have significantly better motor skills in the weeks after spinal cord injury than animals that produce normal SOX2
In the end, researchers may be able to find a safe and effective way to overproduce SOX2 in human spinal cord injury patients, thereby helping them repair the damage with new neurons while reducing the formation of scar tissue.
(Bioon.
com)
(Bioon.
com)
Information source: com/news/2021-03-protein-overdrive-spinal-cord-injuries.
html">Putting a protein into overdrive to heal spinal cord injuries
html">Putting a protein into overdrive to heal spinal cord injuries
Original source: Cell Stem Cell (2021).
dx.
doi.
org/10.
1016/j.
stem.
2021.
02.
009
dx.
doi.
org/10.
1016/j.
stem.
2021.
02.
009
The researchers used mouse spinal cord injury models to search for markers normally found in immature neurons in the injured spinal cord of animals.
The authors not only found this marker in the spinal cord after injury, but also tracked the cells that produced it: non-neuronal cells called NG2 glial cells.
The authors not only found this marker in the spinal cord after injury, but also tracked the cells that produced it: non-neuronal cells called NG2 glial cells.
NG2 glial cells are the progenitor cells of oligodendrocytes, and oligodendrocytes produce an insulating fat layer surrounding neurons.
As we all know, they form colloidal scars after being injured.
Zhang's team showed that when the spinal cord is injured, these glial cells temporarily adopt the molecular and morphological markers of immature neurons.
As we all know, they form colloidal scars after being injured.
Zhang's team showed that when the spinal cord is injured, these glial cells temporarily adopt the molecular and morphological markers of immature neurons.
In order to determine the cause of the changes in NG2 glial cells, the researchers focused on SOX2 (a stem cell protein induced by damage).
They genetically manipulated these cells to inactivate the gene that makes the protein.
After severing the spinal cord of the manipulated mouse, the researchers saw far fewer immature neurons in the days after the injury, indicating that SOX2 plays a key role in helping NG2 glial cells make these cells.
.
However, even if SOX2 levels are normal, these immature neurons will never mature to replace the damaged neurons.
They genetically manipulated these cells to inactivate the gene that makes the protein.
After severing the spinal cord of the manipulated mouse, the researchers saw far fewer immature neurons in the days after the injury, indicating that SOX2 plays a key role in helping NG2 glial cells make these cells.
.
However, even if SOX2 levels are normal, these immature neurons will never mature to replace the damaged neurons.
Instead, Zhang and his colleagues used another genetic manipulation technique to overproduce SOX2 in NG2 glial cells.
Excitingly, within a few weeks after spinal cord injury, the mice undergoing this manipulation produced tens of thousands of new mature neurons.
Further research has shown that these neurons are integrated into the injured area and establish new connections with existing neurons, which are necessary for the transmission of signals between the brain and the body.
Excitingly, within a few weeks after spinal cord injury, the mice undergoing this manipulation produced tens of thousands of new mature neurons.
Further research has shown that these neurons are integrated into the injured area and establish new connections with existing neurons, which are necessary for the transmission of signals between the brain and the body.
More hopefully, this genetic engineering has led to improved function after spinal cord injury.
Animals engineered to overproduce SOX2 in NG2 glial cells have significantly better motor skills in the weeks after spinal cord injury than animals that produce normal SOX2
Animals engineered to overproduce SOX2 in NG2 glial cells have significantly better motor skills in the weeks after spinal cord injury than animals that produce normal SOX2
In the end, researchers may be able to find a safe and effective way to overproduce SOX2 in human spinal cord injury patients, thereby helping them repair the damage with new neurons while reducing the formation of scar tissue.
(Bioon.
com)
(Bioon.
com)
Information source: com/news/2021-03-protein-overdrive-spinal-cord-injuries.
html">Putting a protein into overdrive to heal spinal cord injuries
html">Putting a protein into overdrive to heal spinal cord injuries
Original source: Cell Stem Cell (2021).
dx.
doi.
org/10.
1016/j.
stem.
2021.
02.
009
dx.
doi.
org/10.
1016/j.
stem.
2021.
02.
009
NG2 glial cells are the progenitor cells of oligodendrocytes, and oligodendrocytes produce an insulating fat layer surrounding neurons.
As we all know, they form colloidal scars after being injured.
Zhang's team showed that when the spinal cord is injured, these glial cells temporarily adopt the molecular and morphological markers of immature neurons.
As we all know, they form colloidal scars after being injured.
Zhang's team showed that when the spinal cord is injured, these glial cells temporarily adopt the molecular and morphological markers of immature neurons.
In order to determine the cause of the changes in NG2 glial cells, the researchers focused on SOX2 (a stem cell protein induced by damage).
They genetically manipulated these cells to inactivate the gene that makes the protein.
After severing the spinal cord of the manipulated mouse, the researchers saw far fewer immature neurons in the days after the injury, indicating that SOX2 plays a key role in helping NG2 glial cells make these cells.
.
However, even if SOX2 levels are normal, these immature neurons will never mature to replace the damaged neurons.
They genetically manipulated these cells to inactivate the gene that makes the protein.
After severing the spinal cord of the manipulated mouse, the researchers saw far fewer immature neurons in the days after the injury, indicating that SOX2 plays a key role in helping NG2 glial cells make these cells.
.
However, even if SOX2 levels are normal, these immature neurons will never mature to replace the damaged neurons.
Instead, Zhang and his colleagues used another genetic manipulation technique to overproduce SOX2 in NG2 glial cells.
Excitingly, within a few weeks after spinal cord injury, the mice undergoing this manipulation produced tens of thousands of new mature neurons.
Further research has shown that these neurons are integrated into the injured area and establish new connections with existing neurons, which are necessary for the transmission of signals between the brain and the body.
Excitingly, within a few weeks after spinal cord injury, the mice undergoing this manipulation produced tens of thousands of new mature neurons.
Further research has shown that these neurons are integrated into the injured area and establish new connections with existing neurons, which are necessary for the transmission of signals between the brain and the body.
More hopefully, this genetic engineering has led to improved function after spinal cord injury.
Animals engineered to overproduce SOX2 in NG2 glial cells have significantly better motor skills in the weeks after spinal cord injury than animals that produce normal SOX2
Animals engineered to overproduce SOX2 in NG2 glial cells have significantly better motor skills in the weeks after spinal cord injury than animals that produce normal SOX2
In the end, researchers may be able to find a safe and effective way to overproduce SOX2 in human spinal cord injury patients, thereby helping them repair the damage with new neurons while reducing the formation of scar tissue.
(Bioon.
com)
(Bioon.
com)
Information source: com/news/2021-03-protein-overdrive-spinal-cord-injuries.
html">Putting a protein into overdrive to heal spinal cord injuries
html">Putting a protein into overdrive to heal spinal cord injuries
Original source: Cell Stem Cell (2021).
dx.
doi.
org/10.
1016/j.
stem.
2021.
02.
009
dx.
doi.
org/10.
1016/j.
stem.
2021.
02.
009
In order to determine the cause of the changes in NG2 glial cells, the researchers focused on SOX2 (a stem cell protein induced by damage).
They genetically manipulated these cells to inactivate the gene that makes the protein.
After severing the spinal cord of the manipulated mouse, the researchers saw far fewer immature neurons in the days after the injury, indicating that SOX2 plays a key role in helping NG2 glial cells make these cells.
.
However, even if SOX2 levels are normal, these immature neurons will never mature to replace the damaged neurons.
They genetically manipulated these cells to inactivate the gene that makes the protein.
After severing the spinal cord of the manipulated mouse, the researchers saw far fewer immature neurons in the days after the injury, indicating that SOX2 plays a key role in helping NG2 glial cells make these cells.
.
However, even if SOX2 levels are normal, these immature neurons will never mature to replace the damaged neurons.
Instead, Zhang and his colleagues used another genetic manipulation technique to overproduce SOX2 in NG2 glial cells.
Excitingly, within a few weeks after spinal cord injury, the mice undergoing this manipulation produced tens of thousands of new mature neurons.
Further research has shown that these neurons are integrated into the injured area and establish new connections with existing neurons, which are necessary for the transmission of signals between the brain and the body.
Excitingly, within a few weeks after spinal cord injury, the mice undergoing this manipulation produced tens of thousands of new mature neurons.
Further research has shown that these neurons are integrated into the injured area and establish new connections with existing neurons, which are necessary for the transmission of signals between the brain and the body.
More hopefully, this genetic engineering has led to improved function after spinal cord injury.
Animals engineered to overproduce SOX2 in NG2 glial cells have significantly better motor skills in the weeks after spinal cord injury than animals that produce normal SOX2
Animals engineered to overproduce SOX2 in NG2 glial cells have significantly better motor skills in the weeks after spinal cord injury than animals that produce normal SOX2
In the end, researchers may be able to find a safe and effective way to overproduce SOX2 in human spinal cord injury patients, thereby helping them repair the damage with new neurons while reducing the formation of scar tissue.
(Bioon.
com)
(Bioon.
com)
Information source: com/news/2021-03-protein-overdrive-spinal-cord-injuries.
html">Putting a protein into overdrive to heal spinal cord injuries
html">Putting a protein into overdrive to heal spinal cord injuries
Original source: Cell Stem Cell (2021).
dx.
doi.
org/10.
1016/j.
stem.
2021.
02.
009
dx.
doi.
org/10.
1016/j.
stem.
2021.
02.
009
Instead, Zhang and his colleagues used another genetic manipulation technique to overproduce SOX2 in NG2 glial cells.
Excitingly, within a few weeks after spinal cord injury, the mice undergoing this manipulation produced tens of thousands of new mature neurons.
Further research has shown that these neurons are integrated into the injured area and establish new connections with existing neurons, which are necessary for the transmission of signals between the brain and the body.
Excitingly, within a few weeks after spinal cord injury, the mice undergoing this manipulation produced tens of thousands of new mature neurons.
Further research has shown that these neurons are integrated into the injured area and establish new connections with existing neurons, which are necessary for the transmission of signals between the brain and the body.
More hopefully, this genetic engineering has led to improved function after spinal cord injury.
Animals engineered to overproduce SOX2 in NG2 glial cells have significantly better motor skills in the weeks after spinal cord injury than animals that produce normal SOX2
Animals engineered to overproduce SOX2 in NG2 glial cells have significantly better motor skills in the weeks after spinal cord injury than animals that produce normal SOX2
In the end, researchers may be able to find a safe and effective way to overproduce SOX2 in human spinal cord injury patients, thereby helping them repair the damage with new neurons while reducing the formation of scar tissue.
(Bioon.
com)
(Bioon.
com)
Information source: com/news/2021-03-protein-overdrive-spinal-cord-injuries.
html">Putting a protein into overdrive to heal spinal cord injuries
html">Putting a protein into overdrive to heal spinal cord injuries
Original source: Cell Stem Cell (2021).
dx.
doi.
org/10.
1016/j.
stem.
2021.
02.
009
dx.
doi.
org/10.
1016/j.
stem.
2021.
02.
009
More hopefully, this genetic engineering has led to improved function after spinal cord injury.
Animals engineered to overproduce SOX2 in NG2 glial cells have significantly better motor skills in the weeks after spinal cord injury than animals that produce normal SOX2
Animals engineered to overproduce SOX2 in NG2 glial cells have significantly better motor skills in the weeks after spinal cord injury than animals that produce normal SOX2
In the end, researchers may be able to find a safe and effective way to overproduce SOX2 in human spinal cord injury patients, thereby helping them repair the damage with new neurons while reducing the formation of scar tissue.
(Bioon.
com)
(Bioon.
com)
Information source: com/news/2021-03-protein-overdrive-spinal-cord-injuries.
html">Putting a protein into overdrive to heal spinal cord injuries
html">Putting a protein into overdrive to heal spinal cord injuries
Original source: Cell Stem Cell (2021).
dx.
doi.
org/10.
1016/j.
stem.
2021.
02.
009
dx.
doi.
org/10.
1016/j.
stem.
2021.
02.
009
In the end, researchers may be able to find a safe and effective way to overproduce SOX2 in human spinal cord injury patients, thereby helping them repair the damage with new neurons while reducing the formation of scar tissue.
(Bioon.
com)
(Bioon.
com)
Information source: com/news/2021-03-protein-overdrive-spinal-cord-injuries.
html">Putting a protein into overdrive to heal spinal cord injuries
html">Putting a protein into overdrive to heal spinal cord injuries
Original source: Cell Stem Cell (2021).
dx.
doi.
org/10.
1016/j.
stem.
2021.
02.
009
dx.
doi.
org/10.
1016/j.
stem.
2021.
02.
009
Information source: com/news/2021-03-protein-overdrive-spinal-cord-injuries.
html">Putting a protein into overdrive to heal spinal cord injuries
Information source: com/news/2021-03-protein-overdrive-spinal-cord-injuries. html">Putting a protein into overdrive to heal spinal cord injuries
Original source: Cell Stem Cell (2021).
dx.
doi.
org/10.
1016/j.
stem.
2021.
02.
009
dx.
doi.
org/10.
1016/j.
stem.
2021.
02.
009
html">Putting a protein into overdrive to heal spinal cord injuries
Original source: Cell Stem Cell (2021).
dx.
doi.
org/10.
1016/j.
stem.
2021.
02.
009
dx.
doi.
org/10.
1016/j.
stem.
2021.
02.
009
Original source: Cell Stem Cell (2021).
dx.
doi.
org/10.
1016/j.
stem.
2021.
02.
009
Original source: Cell Stem Cell dx. dx.
doi.
org/10.
1016/j.
stem.
2021.
02.
009
doi.
org/10.
1016/j.
stem.
2021.
02.
009
