Cell Stem Cell: Up-regulating the expression of lamin B1 makes aging neural stem cells rejuvenate

February 28, 2021 News/bioon.
com" target="_blank">/---As people age, their neural bioon.
com/tags/%E5%B9%B2%E7%BB%86%E8%83%9E/">stem cells lose the ability to proliferate and produce new neurons, which leads to a decline in memory function.
Now, in a new study, researchers from the University of Zurich in Switzerlandbioon.
com/course_video/gan-xi-bao-zhi-liao-ji-qi-gui-fan-hua678956.
html">bioon.
com/tags/%E5%B9%B2%E7%BB%86%E8%83%9E/">The mechanism of bioon.
com/tags/%E5%B9%B2%E7%BB%86%E8%83%9E/">stem cell aging and how to reactivate the production of neurons.
The relevant research results were published online in Cell Stem Cell on February 24, 2021, with the title of the paper "Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity".

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Picture from Cell Stem Cell, 2021, doi:10.

1016/j.

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Distribution of age-dependent cell damage

In this new study, Professor Sebastian Jessberger of the Brain Research Institute of the University of Zurich and his research team showed how the formation of new neurons is impaired with age.
The protein structure in the nucleus of neural stem cells ensures that harmful proteins accumulated over time are unevenly distributed to the two daughter cells during cell division.
This seems to be an important part of the long-term proliferation of these bioon.
com/course_video/gan-xi-bao-zhi-liao-ji-qi-gui-fan-hua678956.
html">stem cells to maintain the supply of neurons.
However, as we age, the number of nuclear proteins changes, resulting in defects in the distribution of harmful proteins between the two daughter cells.
This resulted in a decrease in the number of newly generated neurons in the brains of older mice.

bioon.
com/course_video/gan-xi-bao-zhi-liao-ji-qi-gui-fan-hua678956.
html">stem cell

The core element in this process is a nuclear protein called lamin B1 (lamin B1), the level of which decreases as a person ages.
When the authors increased the level of lamin B1 in experiments with aging mice, the division of neural stem cells improved and the number of new neurons increased.
The first author of the paper, Khadeesh bin Imtiaz, a PhD student at the Institute of Brain Research at the University of Zurich, said, “As we age, bioon.
com/course_video/gan-xi-bao-zhi-liao-ji-qi-gui-fan-hua678956.
html">stem cells throughout the body will gradually lose their ability to proliferate.
Using genetic engineering and cutting-edge microscopy technology, we can identify a kind of Process-related mechanisms.
"

bioon.
com/course_video/gan-xi-bao-zhi-liao-ji-qi-gui-fan-hua678956.
html">stem cell

Stop the aging process of neural bioon.
com/course_video/gan-xi-bao-zhi-liao-ji-qi-gui-fan-hua678956.
html">stem cells

Stop the aging process of neural bioon.
com/course_video/gan-xi-bao-zhi-liao-ji-qi-gui-fan-hua678956.
html">stem cellsbioon.
com/course_video/gan-xi-bao-zhi-liao-ji-qi-gui-fan-hua678956.
html"> stem cells

This research is part of several ongoing projects aimed at reactivating aging stem cells.
With age, the regeneration ability of damaged tissues generally declines, which affects almost all types of bioon.
com/course_video/gan-xi-bao-zhi-liao-ji-qi-gui-fan-hua678956.
html">stem cells in the body .

bioon.
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html">stem cell

Jessberger said, "Although our research is limited to neural stem cells in the brain, when it comes to the aging process of other bioon.
com/course_video/gan-xi-bao-zhi-liao-ji-qi-gui-fan-hua678956.
html">stem cells , similar mechanisms are likely to play a key role.
"

bioon.
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html">stem cell

These latest findings are an important step in exploring age-dependent changes in stem cell behavior.
Jessberger said, "We now know that we can reactivate aging neural stem cells in the brain.
We hope that these findings will one day help increase the level of neurogenesis, such as in the elderly or suffering from degenerative diseases (such as Alzheimer's disease).
Of people.
Even if this may still be many years from now.
" (Bioon.
com)

References: 1.

Muhammad Khadeeshbin Imtiaz et al.
org/10.

References: 1.
Muhammad Khadeeshbin Imtiaz et al.
org/10.
1016/j.
stem.
2021.
01.
015" target="_blank">Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity .
Cell Stem Cell, 2021, doi:10.
1016/j.
stem.
2021.
01.
015.
2.
Reactivating aging stem cells in the brain
https://medicalxpress.
com/news/2021-02-reactivating-aging-stem-cells-brain.
html org/10.
1016/j.
stem.
2021.
01.
015" target="_blank">Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity