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This article was originally written by Translational Medicine.
Please indicate the source.
Author: Jasmine Introduction: The incidence of pancreatic cancer ranks 13th among malignant tumors, and it does not belong to the top ten most common tumors, but its mortality rate ranks among tumors.
8th in related deaths
.
Pancreatic cancer has poor prognosis, short median survival time and high mortality rate, so it is called "the king of cancer"
.
Existing treatments can only extend patients' lives by six months to a year, and recently, researchers found that a ketogenic diet combined with chemotherapy could triple the survival of pancreatic cancer patients compared to chemotherapy alone
.
A preclinical study at the Ludwig Institute for Cancer Research shows that a common weight-loss diet, known as the ketogenic diet, can improve the efficacy of chemotherapy for pancreatic cancer
.
The study, published in the journal Med, shows that in a mouse model of pancreatic ductal carcinoma (PDAC), a ketogenic diet (high fat, moderate protein, and very low carbohydrate intake) works synergistically with chemotherapy to enable small Mice survived three times as long as chemotherapy alone
.
Titled: "Ketogenic diet and chemotherapy combine to disrupt pancreatic cancer metabolism and growth," the study describes how the ketogenic diet affects PDAC tumor metabolism and identifies mechanisms that may explain the therapeutic effects
.
https://doi.
org/10.
1016/j.
medj.
2021.
12.
008 "Real progress has been made in the treatment of pancreatic cancer over the past 20 years
.
said Rabinowitz, who is also a professor in Princeton's Department of Chemistry and the Lewis-Sigler Institute for Integrative Genomics
.
"But the problem is that while many patients now see their tumors stabilize or shrink, the benefits of chemotherapy are very short-lived
.
Chemotherapy usually only prolongs the lifespan of patients by six months to a year, and almost no patients can prolong their survival by more than three years through chemotherapy, which is an unimaginable luxury for pancreatic cancer patients
.
"There is substantial preclinical evidence that the metabolic effects of fasting or fasting-like diets can enhance the treatment of a variety of cancers
.
The
ketogenic diet mimics fasting by lowering circulating glucose and lowering insulin levels, a form of A hormone that prompts tissues and tumors to consume sugar
.
Insulin is an important promoter of cancer growth, especially in pancreatic tumors, and glucose is an important fuel for cancer cell proliferation
.
Rabinowitz's own previous research has shown that although PDAC tumors grow vigorously, they The lack of glucose suggests that they may be particularly vulnerable to additional glucose deprivation
.
With continued support from Stand Up to Cancer, Rabinowitz and his colleagues have conducted multiple experiments over the years
.
They used small children with pancreatic cancer.
In a murine model, mice were fed a normal (carbohydrate-rich) diet and a ketogenic diet and were treated with a standard combination of chemotherapy—nab-paclitaxel, gemcitabine, and cisplatin
.
They found that the ketogenic diet alone did not affect the Tumor growth
.
But when combined with chemotherapy, it did triple median survival
.
Notably, although the therapeutic effect did not depend on the immune system, only mice with an intact immune system were among the long-lived mice
.
Under ketogenic diet conditions, survival from chemotherapy increased approximately threefold.
Rabinowitz and his team also conducted a study to explore the effect of the combination therapy on tumor metabolism
.
"We know that glucose is a major cancer fuel and insulin is a cancer-promoting hormone, and a ketogenic diet reduces both hormones," Rabinowitz said
.
"We found in this study that a ketogenic diet can Lowers glucose levels in tumors and significantly suppresses insulin levels
.
" By depriving the body of sugar, a ketogenic diet forces the body to break down fat to create molecules called ketone bodies, which can be burned by cells for energy
.
Chief among them is 3-hydroxybutyric acid, which acts like a supercharged fuel, dumping electrons into the cell, and tumor cells, for some other reason, are particularly good at absorbing this fuel, while too much 3-Hydroxybutyric acid may be toxic to cancer
.
This excess of electrons leads to the production of reactive oxygen species (ROS), and chemotherapy can also generate this extremely unstable molecule
.
Reactive oxygen species kill cancer cells by damaging DNA, cell membranes and other cellular components
.
The researchers speculate that this may enhance the antitumor effects of chemotherapy
.
Their findings are currently being evaluated in a clinical trial (NCT04631445) testing the benefit of a ketogenic diet in PDAC patients undergoing chemotherapy
.
The research by Rabinowitz and his team laid the groundwork for a clinical trial of the combination of a ketogenic diet and chemotherapy for pancreatic cancer
.
Humanity is one step closer to conquering the "king of cancer" - pancreatic cancer! Reference: https://medicalxpress.
com/news/2022-02-preclinical-ketogenic-diet-pancreatic-cancer.
html Note: This article aims to introduce the progress of medical research and cannot be used as a reference for treatment plans
.
For health guidance, please go to a regular hospital for treatment
.
Recommendation·Events The First Yangtze River Delta Single Cell Omics Technology Application Forum [Webinar] Synthetic Biology Innovation and Development Popularity·Articles Stem Cell Research [Nature Sub-Journal] Using Stem Cells to Regenerate the Heart! Gene sequencing [Nature sub-journal] Analysis of 2658 complete DNA sequences - providing new clues for cancer mutations Cancer research [Science sub-journal] Will "lactic acid" help cancer cells? Studies have found that specific enzymes can fight it! Single-cell omics [guest announcement] The first Yangtze River Delta single-cell omics technology forum will be held in Shanghai in early March.
The second issue of precision medicine "Precision Medicine" is coming! What kind of sparks can CAR-T and MRD collide with? Big coffee gathered to explain to you! Detection and diagnosis [Nature sub-journal] Fudan University Wei Dacheng's team and academician Liu Yunqi have developed an ultra-high-sensitivity detection portable device that can produce results in 4 minutes! PCR detection or be replaced!
Please indicate the source.
Author: Jasmine Introduction: The incidence of pancreatic cancer ranks 13th among malignant tumors, and it does not belong to the top ten most common tumors, but its mortality rate ranks among tumors.
8th in related deaths
.
Pancreatic cancer has poor prognosis, short median survival time and high mortality rate, so it is called "the king of cancer"
.
Existing treatments can only extend patients' lives by six months to a year, and recently, researchers found that a ketogenic diet combined with chemotherapy could triple the survival of pancreatic cancer patients compared to chemotherapy alone
.
A preclinical study at the Ludwig Institute for Cancer Research shows that a common weight-loss diet, known as the ketogenic diet, can improve the efficacy of chemotherapy for pancreatic cancer
.
The study, published in the journal Med, shows that in a mouse model of pancreatic ductal carcinoma (PDAC), a ketogenic diet (high fat, moderate protein, and very low carbohydrate intake) works synergistically with chemotherapy to enable small Mice survived three times as long as chemotherapy alone
.
Titled: "Ketogenic diet and chemotherapy combine to disrupt pancreatic cancer metabolism and growth," the study describes how the ketogenic diet affects PDAC tumor metabolism and identifies mechanisms that may explain the therapeutic effects
.
https://doi.
org/10.
1016/j.
medj.
2021.
12.
008 "Real progress has been made in the treatment of pancreatic cancer over the past 20 years
.
said Rabinowitz, who is also a professor in Princeton's Department of Chemistry and the Lewis-Sigler Institute for Integrative Genomics
.
"But the problem is that while many patients now see their tumors stabilize or shrink, the benefits of chemotherapy are very short-lived
.
Chemotherapy usually only prolongs the lifespan of patients by six months to a year, and almost no patients can prolong their survival by more than three years through chemotherapy, which is an unimaginable luxury for pancreatic cancer patients
.
"There is substantial preclinical evidence that the metabolic effects of fasting or fasting-like diets can enhance the treatment of a variety of cancers
.
The
ketogenic diet mimics fasting by lowering circulating glucose and lowering insulin levels, a form of A hormone that prompts tissues and tumors to consume sugar
.
Insulin is an important promoter of cancer growth, especially in pancreatic tumors, and glucose is an important fuel for cancer cell proliferation
.
Rabinowitz's own previous research has shown that although PDAC tumors grow vigorously, they The lack of glucose suggests that they may be particularly vulnerable to additional glucose deprivation
.
With continued support from Stand Up to Cancer, Rabinowitz and his colleagues have conducted multiple experiments over the years
.
They used small children with pancreatic cancer.
In a murine model, mice were fed a normal (carbohydrate-rich) diet and a ketogenic diet and were treated with a standard combination of chemotherapy—nab-paclitaxel, gemcitabine, and cisplatin
.
They found that the ketogenic diet alone did not affect the Tumor growth
.
But when combined with chemotherapy, it did triple median survival
.
Notably, although the therapeutic effect did not depend on the immune system, only mice with an intact immune system were among the long-lived mice
.
Under ketogenic diet conditions, survival from chemotherapy increased approximately threefold.
Rabinowitz and his team also conducted a study to explore the effect of the combination therapy on tumor metabolism
.
"We know that glucose is a major cancer fuel and insulin is a cancer-promoting hormone, and a ketogenic diet reduces both hormones," Rabinowitz said
.
"We found in this study that a ketogenic diet can Lowers glucose levels in tumors and significantly suppresses insulin levels
.
" By depriving the body of sugar, a ketogenic diet forces the body to break down fat to create molecules called ketone bodies, which can be burned by cells for energy
.
Chief among them is 3-hydroxybutyric acid, which acts like a supercharged fuel, dumping electrons into the cell, and tumor cells, for some other reason, are particularly good at absorbing this fuel, while too much 3-Hydroxybutyric acid may be toxic to cancer
.
This excess of electrons leads to the production of reactive oxygen species (ROS), and chemotherapy can also generate this extremely unstable molecule
.
Reactive oxygen species kill cancer cells by damaging DNA, cell membranes and other cellular components
.
The researchers speculate that this may enhance the antitumor effects of chemotherapy
.
Their findings are currently being evaluated in a clinical trial (NCT04631445) testing the benefit of a ketogenic diet in PDAC patients undergoing chemotherapy
.
The research by Rabinowitz and his team laid the groundwork for a clinical trial of the combination of a ketogenic diet and chemotherapy for pancreatic cancer
.
Humanity is one step closer to conquering the "king of cancer" - pancreatic cancer! Reference: https://medicalxpress.
com/news/2022-02-preclinical-ketogenic-diet-pancreatic-cancer.
html Note: This article aims to introduce the progress of medical research and cannot be used as a reference for treatment plans
.
For health guidance, please go to a regular hospital for treatment
.
Recommendation·Events The First Yangtze River Delta Single Cell Omics Technology Application Forum [Webinar] Synthetic Biology Innovation and Development Popularity·Articles Stem Cell Research [Nature Sub-Journal] Using Stem Cells to Regenerate the Heart! Gene sequencing [Nature sub-journal] Analysis of 2658 complete DNA sequences - providing new clues for cancer mutations Cancer research [Science sub-journal] Will "lactic acid" help cancer cells? Studies have found that specific enzymes can fight it! Single-cell omics [guest announcement] The first Yangtze River Delta single-cell omics technology forum will be held in Shanghai in early March.
The second issue of precision medicine "Precision Medicine" is coming! What kind of sparks can CAR-T and MRD collide with? Big coffee gathered to explain to you! Detection and diagnosis [Nature sub-journal] Fudan University Wei Dacheng's team and academician Liu Yunqi have developed an ultra-high-sensitivity detection portable device that can produce results in 4 minutes! PCR detection or be replaced!
