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    Home > Active Ingredient News > Immunology News > [Cell Sub-issue] High sugar does promote inflammation!

    [Cell Sub-issue] High sugar does promote inflammation!

    • Last Update: 2022-04-29
    • Source: Internet
    • Author: User
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    This article was originally written by Translational Medicine Network.
    Please indicate the source when reprinting
    .

    In people with autoimmune diseases, the immune system attacks the body's own tissues, such as chronic inflammatory bowel disease (such as Crohn's disease and ulcerative colitis), type 1 diabetes, and chronic inflammation of the thyroid
    .

    The underlying molecular mechanisms that promote autoimmune disease progression are complex and multi-layered
    .

    Scientists at the University of Würzburg (JMU) have succeeded in deciphering the underlying molecular mechanisms that promote autoimmune diseases
    .

    Their research suggests that excessive intake of glucose directly promotes the pathogenic function of certain cells of the immune system, and that, conversely, a reduced-calorie diet can have beneficial effects on immune diseases
    .

    Based on these findings, they also identified new targets for therapeutic intervention: blocking glucose-dependent metabolic processes in these immune cells to suppress excessive immune responses
    .

    The findings were recently published in the journal Cell Metabolism, titled: "The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming"
    .

    https://doi.
    org/10.
    1016/j.
    cmet.
    2022.
    02.
    015 Glucose transporter with 'sideline' explains Dr Martin Väth, who led the study: "Immune cells require large amounts of sugar in the form of glucose to complete their Task
    .

    With the help of special transporters on the cell membrane, they can take up glucose from the environment
    .

    "Väth and his team demonstrated that a special glucose transporter scientifically named GLUT3 performs additional metabolic functions in T cells in addition to producing energy from sugar
    .

    In their study, the scientists focused on placed on a lesser-known group of cells in the immune system: Type 17 T helper cells, also known as Th17 lymphocytes, which play an important role in regulating (auto)inflammatory processes
    .

    "These Th17 cells are on the cell surface .
    Expresses a large amount of the GLUT3 protein,” explains Väth
    .

    Once absorbed, glucose is easily converted to citrate in the mitochondria and then metabolized to acetyl-CoA (acetyl-CoA) in the cytoplasm
    .

    Acetyl-CoA is involved in many metabolic processes, including lipid Biosynthesis of cytoplasm
    .

    Graphical summary of effects on pro-inflammatory genes Acetyl-CoA, however, has other functions in inflammatory Th17 cells
    .

    Väth and his team showed that this metabolic intermediate can also regulate the activity of various gene fragments Therefore
    ,
    glucose intake has a direct effect on the activity of pro-inflammatory genes
    .

    The researchers say these new findings pave the way for the development of targeted treatments for autoimmune diseases
    .

    For example, by the dietary supplement hydroxycitrate (used for Obesity treatment) Blockade of GLUT3-dependent acetyl-CoA synthesis can alleviate the pathogenic function of Th17 cells and reduce inflammatory pathological processes
    .

    T cell "metabolic reprogramming" offers new possibilities for the treatment of autoimmune diseases without Impairs the function of protective immune cells
    .

    Reference: https://medicalxpress.
    com/news/2022-03-sugar-inflammation.
    html Note: This article aims to introduce the progress of medical research and cannot be used as a reference for treatment plans
    .

    For health guidance, please go to a regular hospital for treatment
    .

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