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    Home > Active Ingredient News > Digestive System Information > 【Cell Sub-issue】Cell regeneration therapy, restore damaged liver tissue faster!

    【Cell Sub-issue】Cell regeneration therapy, restore damaged liver tissue faster!

    • Last Update: 2022-05-27
    • Source: Internet
    • Author: User
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    This article was originally written by Translational Medicine.
    Please indicate the source.
    Author: Ashley Introduction: Recent research has found a way to partially reset liver cells to a younger state - allowing them to operate at a faster rate than previously observed Heal damaged tissue
    .

    The study used the Yamanaka factor to see if it could increase liver size and improve liver function while extending the healthy span of mice
    .

    The process involves partially converting mature liver cells back to a "young" state, thereby promoting cell growth, revealing that the use of reprogramming molecules can improve cell growth and lead to better liver tissue regeneration in mice
    .

    Mammals generally cannot regenerate organs as efficiently as other vertebrates, such as fish and lizards
    .

    Now, Salk scientists have found a way to partially reset liver cells to a younger state -- allowing them to heal damaged tissue at a faster rate than previously observed
    .

    The work "In vivo partial cellular reprogramming enhances liver plasticity and regeneration", published in Cell Reports on April 26, 2022, revealed that the use of reprogramming molecules can improve cell growth, resulting in better liver tissue regeneration in mice
    .

    Juan Carlos Izpisua Belmonte, corresponding author of the article at https:// said: "We are excited about the progress we have made in repairing cells in damaged livers.
    , because approaches like this could one day be extended to replace the entire organ itself
    .

    Our findings could lead to the development of new treatments for infections, cancer and inherited liver diseases, as well as metabolic diseases such as nonalcoholic steatohepatitis (NASH)
    .

    The authors have previously shown how four cell-reprogramming molecules -- Oct-3/4, Sox2, Klf4 and c-Myc, also known as the "Yamaka factor" -- can slow the aging process and improve muscle tissue regeneration in mice ability
    .

    In their latest study, the authors used Yamanaka factors to see if they could increase liver size and improve liver function while extending the span of health in mice
    .

    The process involves partially converting mature liver cells back to a "young" state, thereby Promotes cell growth
    .

    “Unlike most of our other organs, the liver is more efficient at repairing damaged tissue,” said co-first author Mako Yamamoto.
    The power of the Yamanaka factor was tested in the model
    .

    "The question facing many researchers in the field is how to control the expression of factors needed to improve cell function and rejuvenation, as some of these molecules cause rampant cell growth, as occurs in cancer
    .

    To avoid this, Izpisua Belmonte's The team used a short-term regimen of Yamanaka factor, in which the mice received only one day of treatment
    .

    The team then tracked the activity of the partially reprogrammed liver cells by taking periodic samples and closely monitoring how the cells divided over several generations
    .

    Even after 9 Months later—about one-third of an animal's lifespan—none of the mice developed tumors
    .

    "The Yamanaka factor is really a double-edged sword," said co-first author Tomoaki Hishida.
    "On the one hand, they may Enhances liver regeneration of damaged tissue, but has the disadvantage of causing tumors
    .

    We are excited to find that our short-term induction protocol has good results
    .

    "Scientists have made a second discovery while studying this reprogramming mechanism in a lab dish: A gene called Top2a is involved in liver cell reprogramming and is expressed a day after short-term Yamanaka factor treatment.
    " were highly active
    .

    Top2a encodes topoisomerase 2a, an enzyme that helps break and reconnect DNA strands
    .

    When the researchers blocked the gene that reduces topoisomerase 2a levels, they saw a reduction in the rate of cellular reprogramming 40 times, resulting in far fewer young cells
    .

    The exact role that Top2a plays in this process remains an area of ​​future research
    .

    Izpisua Belmonte said: "There is still a lot to be done before we can fully understand the molecular basis of how cells are programmed to rejuvenate work to be done
    .

    This is a necessary requirement for developing effective, universal medical treatments and reversing the effects of human disease
    .

    "Reference: https://medicalxpress.
    com/news/2022-04-cellular-regeneration-therapy-liver-tissue.
    html Note: This article aims to introduce the progress of medical research and cannot be used as a reference for treatment plans
    .

    For health guidance , please go to a regular hospital for treatment
    .

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