Cell sub-journal: Although dietary fiber is good, intake also varies from person to person

Dietary fiber mainly refers to carbohydrates present in plants .


fruits, vegetables, legumes, nuts, seeds and grains) that cannot be digested by the human body but can be selectively metabolized by the gut microflo.

Once nourished with dietary fiber, the gut microbiota is involved in many beneficial biochemical processes, including the fermentation of carbohydrates into short-chain fatty acids (SCFAs), the synthesis of important vitamins such as K and B vitamins ), as well as activate the immune syst.

Dietary fiber mainly refers to carbohydrates present in plants .


fruits, vegetables, legumes, nuts, seeds and grains) that cannot be digested by the human body but can be selectively metabolized by the gut microflo.

Once nourished with dietary fiber, the gut microbiota is involved in many beneficial biochemical processes, including the fermentation of carbohydrates into short-chain fatty acids (SCFAs), the synthesis of important vitamins such as K and B vitamins ), as well as activate the immune syst.

Digestive Immunity Recently, the team of Professor Michael Snyder of Stanford School of Medicine published a research result entitled "Global, distinctive, and personal changes in molecular and microbial profiles by specific fibers in humans" in the internationally renowned journal Cell Host & Microbe ( Figure
Research shows that each type of fiber elicits individualized and fiber-specific biochemical and microbiota responses, so the health benefits of dietary fiber vary from person to person and may also depend on the specific fiber type and intake dose

Cell Host & Microbe research shows that each fiber can elicit individualized and fiber-specific biochemical and microbiome responses, so the health benefits of dietary fiber vary from person to person and may also depend on specific fiber intake Types and intake doses 

Figure 1 Research results (Source: Cell Host & Microbe ) 

Figure 1 Results of the study (Credit: Cell Host & Microbe )Figure 1 Results of the study (Credit: Cell Host & Microbe ) In this study, researchers conducted a longitudinal, randomized, crossover experiment to try to understand two Effects of common single purified fibers Arabinoxylan (AX) and long-chain inulin (LCI) on gut microbes and huma.

AX is common in whole grains such as rye, wheat, oats, and rice; LCI is found in onions, chicory root, garlic, and artichok.

Both types of fibers are available as dietary supplemen.

 The researchers recruited 18 participants who regularly supplemented with both types of fibers, as well as a fiber blend consisting of equal amounts of AX or LCI, gum arabic, glucomannan, and resistant star.

Participants were randomly assigned to two groups, and fiber supplementation increased from 10 grams per day in the first week (breakfast) to 20 grams per day in the second week (10 grams for breakfast and 10 grams for dinner), and finally increased to 30 grams per day in the third we.

grams (10 grams each for breakfast, lunch and dinne.

Finally, by analyzing fecal metagenomics, plasma proteomics, metabolomics, lipidomics, serum cytokines, and clinical data, the researchers revealed that AX, LCI and mixed fiber play a role in gut microbiota and human metabolism and inflammati.

unique and individualized role (F.


 

Figure 2 Overview of the study design (Source: Cell Host & Microbe )

Figure 2 Overview of study design (Source: Cell Host & Microbe ) Figure 2 Overview of study design (Source: Study Design Cell Host & Microbe ) The researchers first measured the effect of different omics intensities by using the coefficient of variation (C.

inter-individual variatio.

The results showed that there were significant differences in the CV distributions among the various omic.

Second, the composition of the microbiota changed during all dietary fiber interventions, with a decrease in microbial Shannon diversity (F.

3.

Figure 3 General biological effects of dietary fiber (Source: Cell Host & Microbe )

Figure 3 General biological effects of dietary fiber (Image source: Cell Host & Microbe ) Figure 3 General biological effects of dietary fiber (Image source: Cell Host & Microbe Cell Host & Microbe )

Next, the researchers delved into the impact of individual purified fibers on clinically relevant analyses and multi-omics measur.

The results of the study showed that during the period of consuming AX, the participants' blood lipid profile improved, and the body's low-density lipoprotein (full name, LDL, "bad" cholesterol ), total cholesterol and other lipid levels decreased (Figure 4)

However, individual responses vari.

Some participants had little change in cholesterol levels, while some participants had the greatest reductions in cholesterol .


, strong responders), exhibiting different systemic responses, including having more phenolic acid metabolism-related genes in their metagenomes and Lower clinical triglycerid.

Next, the researchers delved into the impact of individual purified fibers on clinically relevant analyses and multi-omics measur.

The results of the study showed that during the period of consuming AX, the participants' blood lipid profile improved, and the body's low-density lipoprotein (full name, LDL, "bad" cholesterol ), total cholesterol and other lipid levels decreased (Figure 4)

However, individual responses vari.

Some participants had little change in cholesterol levels, while some participants had the greatest reductions in cholesterol .


, strong responders), exhibiting different systemic responses, including having more phenolic acid metabolism-related genes in their metagenomes and Lower clinical triglycerid.

During the intake of AX, the participants' lipid profile improved, and the body's low-density lipoprotein (full name, LDL, "bad" cholesterol ), total cholesterol, and other lipid levels decreased (Figure
Cholesterol

In addition, further studies have shown that cholesterol lowering by AX is associated with increased bile acid secretion or other changes in bi.

In particular, the researchers found that bile acids increased during the intake of .

In addition to expelling the cholesterol pool, they also act as signaling molecules for cholesterol metabolism, bind to the metabolic nuclear receptors FXR and LXR, and control cholesterol metabolism and its conversion to bile aci.

In addition, further studies have shown that cholesterol lowering by AX is associated with increased bile acid secretion or other changes in bi.

In particular, the researchers found that bile acids increased during the intake of .

In addition to expelling the cholesterol pool, they also act as signaling molecules for cholesterol metabolism, bind to the metabolic nuclear receptors FXR and LXR, and control cholesterol metabolism and its conversion to bile aci.

 

Figure 4 System biology changes in the body when taking arabinoxylan (Source: Cell Host & Microbe )

Figure 4 System biology changes in the body when taking arabinoxylan (Source: Cell Host & Microbe ) Cell Host & Microbe

Meanwhile, the results of the study showed that the intake of low-dose LCI was associated with a slight decrease in inflammatory markers and an increase in the abundance of bifidobacteria

Bifidobacterium is an intestinal probiotic that produces healthy short-chain fatty acids in the bo.

However, at high doses of 30 g/day, participants had significantly higher levels of inflammation and Alanine aminotransferase (ALT) in the liver (ALT is a potential marker of liver damage) , indicating that excessive intake of LCI may be harmful to heal.

Meanwhile, the results of the study showed that the intake of low-dose LCI was associated with a slight decrease in inflammatory markers and an increase in the abundance of bifidobacteria

Bifidobacterium is an intestinal probiotic that produces healthy short-chain fatty acids in the bo.

However, at high doses of 30 g/day, participants had significantly higher levels of inflammation and Alanine aminotransferase (ALT) in the liver (ALT is a potential marker of liver damage) , indicating that excessive intake of LCI may be harmful to heal.

Consumption of low-dose LCI was associated with a slight decrease in inflammatory markers and increased abundance of bifidobacter.

However, at high-dose intake of 30 g/day, participants' inflammatory levels and alanine aminotransferase in the liver ( Alanine aminotransferase, ALT) levels will be significantly increased

Dietary fiber can improve human health by modulating the composition and function of the gut microbiota, but different types of fiber supplements may have different effec.

This study revealed the unique and individualized effects of different dietary fiber supplements on gut microbiota and human metabolism and inflammati.

It is worth noting that the results of the study found that the intake of high doses of LCI may lead to some adverse reactions, and the cholesterol-lowering effect of AX also has interindividual differences, suggesting the importance of individualized intervention of dietary fib.

Dietary fiber can improve human health by modulating the composition and function of the gut microbiota, but different types of fiber supplements may have different effec.

This study revealed the unique and individualized effects of different dietary fiber supplements on gut microbiota and human metabolism and inflammati.

It is worth noting that the results of the study found that the intake of high doses of LCI may lead to some adverse reactions, and the cholesterol-lowering effect of AX also has interindividual differences, suggesting the importance of individualized intervention of dietary fib.

Taken together, the findings of this study suggest that the benefits of dietary fiber depend on fiber type, dose, and the individual,.


, a range of factors resulting from the interaction between fiber, gut microbiota, and the ho.

These results are critical for understanding personalized nutrition

Taken together, the findings of this study suggest that the benefits of dietary fiber depend on fiber type, dose, and the individual,.


, a range of factors resulting from the interaction between fiber, gut microbiota, and the ho.

These results are critical for understanding personalized nutrition

Namely, a series of factors resulting from the interaction between fiber, gut microbiota and the ho.

These results are critical for understanding personalized nutritio.

How should dietary fiber be consumed in the daily diet ? How should dietary fiber be consumed in the daily diet ? 

Fiber is an important part of our diet, also known as whole grains, the indigestible part of plant foods and helps reduce the risk of diseases like heart disease and type 2 diabetes

Fiber is an important part of our diet, also known as whole grains, the indigestible part of plant foods and helps reduce the risk of diseases like heart disease and type 2 diabetes

Digestive diabetes

There are two main types of fiber, both non-starch polysaccharides that people cannot digest:

There are two main types of fiber, both non-starch polysaccharides that people cannot digest:

(1) Insoluble fibers mainly include cellulose, part of hemicellulose, lignin,e.

Insoluble dietary fibers have a harder texture, and their main role is to promote intestinal peristalsis and prevent constipati.

(1) Insoluble fibers mainly include cellulose, part of hemicellulose, lignin,e.

Insoluble dietary fibers have a harder texture, and their main role is to promote intestinal peristalsis and prevent constipati.

Insoluble Fiber Prevention

(2) Soluble fibers mainly include pectin, gum, algin, soybean gum, agar, some oligosaccharides and a few hemicellulos.

Generally speaking, soluble dietary fiber has a soft texture and is partially or fully fermented in the large intestine, which can help the body control cholesterol and blood sugar levels and help prevent chronic diseases such as heart disease and diabet.

(2) Soluble fibers mainly include pectin, gum, algin, soybean gum, agar, some oligosaccharides and a few hemicellulos.

Generally speaking, soluble dietary fiber has a soft texture and is partially or fully fermented in the large intestine, which can help the body control cholesterol and blood sugar levels and help prevent chronic diseases such as heart disease and diabet.

soluble fiber

Although the above studies have revealed that the health benefits of dietary fiber vary from person to person, one thing is certain, that proper intake of dietary fiber does have some benefits for the human body , such as increasing satiety and helping obese people reduce food intake; The water absorption of dietary fiber can increase the volume of feces and promote the excretion of feces; reduce the absorption of sugar in the small intestine, reduce the absorption rate of fat and cholesterol, and achieve the effect of lowering blood sugar and blood lipi.

Although the above studies have revealed that the health benefits of dietary fiber vary from person to person, one thing is certain, that proper intake of dietary fiber does have some benefits for the human body , such as increasing satiety and helping obese people reduce food intake; The water absorption of dietary fiber can increase the volume of feces and promote the excretion of feces; reduce the absorption of sugar in the small intestine, reduce the absorption rate of fat and cholesterol, and achieve the effect of lowering blood sugar and blood lipi.

Although the above studies reveal that the health benefits of dietary fiber vary from person to person, one thing is for sure that a proper intake of dietary fiber does have some benefits for the human bod.

The Chinese Nutrition Society recommends that the intake of dietary fiber for adults is 25-35 grams per day, but according to the White Paper on Dietary Fiber Intake of Chinese Residents released in 2016, the dietary fiber intake of Chinese residents is generally insufficient

Therefore, it is very necessary to supplement dietary fib.

The Chinese Nutrition Society recommends that the intake of dietary fiber for adults is 25-35 grams per day, but according to the White Paper on Dietary Fiber Intake of Chinese Residents released in 2016, the dietary fiber intake of Chinese residents is generally insufficient

In short, there are many benefits of dietary fib.

References: [1] Lancaster SM, Lee-McMullen B, Abbott CW, et .
Global, distinctive, and personal changes in molecular and microbial profiles by specific fibers in huma.
Cell Host Micro.
2022 Apr 22:S1931-3128( 22) 00166- doi: 11016.
ch.
202003 Epub ahead of pri.
PMID: 3548336 [2] National Dietary Fiber Day | What exactly is dietary fiber? Why do we need it more and more? leave a message here