Cell Sub-Journal: Anti-spitting drug gastric resusperation can inhibit the proliferation of leukemia stem cells

Chronic myeloid leukemia (CML) is the degeneration of hematopoietic stem cells (leukemia stem cells), which lead to uncontrolled formation of specific white blood cells called granulocytes.
, the authors focused their research on determining the signaling path and control mechanisms of leukemia stem cells.
as an anti-vomiting drug commonly used to treat nausea and vomiting, gastric recovery offers a promising method.
Using gastric compounding specificity to block the proliferation of leukemia stem cells First analyzed and recorded the exact role of the surface molecule CD93 in controlling the proliferation of leukemia stem cells in animal experiments, and then carried out the same analysis and recording in the experiments of leukemia stem cells in patients.
this reveals cd93's unique regulatory function in leukemia stem cells.
this function has been confirmed in animal experiments in the body.
further found that this regulatory function applies only to leukemia stem cells, not normal hematopoietic stem cells.
In addition, the study also showed that gastric resusperation interfered with the signaling path of leukemia stem cell proliferation in vitro, and in animal experiments, by blocking the proliferation of leukemia stem cells, significantly improved the survival rate of CML animal models.
provides strong evidence that gastric reseal may also show positive effects in treating human CRM.
The contribution from many disciplines is necessary to develop a new and promising approach to the fight against CML, and different research methods must be pursued," explains Carsten Riether, co-author and lead author of the paper and a professor at the University of Bern.
in the screening process, we obtained a candidate drug gastric resusperation, and then in vitro and in vivo experiments can confirm its effect on the CD93 signaling path.
" next research activities What are these findings that pinpoint CD93 as a specific regulatory factor responsible for the proliferation of leukemia stem cells.
this identifies a promising path to target leukemia stem cells.
further research is now needed to confirm its clinical effectiveness and relevance.
"Thanks to this pool of professionals, we were able to identify gastric reseal as a promising candidate for the treatment of CML," said Adrian Ochsenbein, co-author of the paper and a professor at the University of Bern.
with our extensive research infrastructure and our excellent national and international network, we expect clinical results within a reasonable time.
" Reference: 1.Carsten Riether et al. Metoclopramide treatment blocks CD93-signaling-mediated self-renewal of chronic myeloid leukemia stem cells. Cell Reports, 2021, doi:10.1016/j.celrep.2020.108663. 2.Metoclopramide inhibits proliferation of leukemia stem cells