Cell Sub-journal: Ketogenic diet of high-fat low-carbon water has been shown to inhibit cancer

Photo Source:but a recent study of the ketogenic diet published in the journal Cell Reports was even more surprising! Researchers at the University of Texas at Dallas have found that a ketogenic diet can prevent cancerthe anticancer effects of the ketogenic dietketogenic diet (Keto Diet, KD), a diet with high fat, low-carbon water and appropriate protein intakeAccording to the hypothesis put forward by Otto Warburg in 1924, malignant tumors rely primarily on glucose oxidation decomposition (also known as glycolysis) to produce ATP as a driving force for proliferationAnd because of the mitochondrial dysfunction of tumor cells, the level of enzymes required to metabolize the ketones is reduced, which causes cancer cells to lack the ability to metabolize ketonesSo, providing a ketogenic diet in cancer treatment can lower glucose levels in the blood and induce ketones, which can cause cancer cells to lack energy and thus inhibit tumor growthBut normal cells survive by adjusting metabolism to use ketones under this dietary conditionGiven this unique metabolic heterogeneity, the ketogenic diet has thus come to the fore for cancer researcherssquamous cell carcinoma and ketogenic dietresearchers from the University of Texas at Dallas also used this as a basis for research on squamous cell carcinoma (SCC), one of the malignant tumorsimage source:researchers selected two groups of mice with squamous cell lung and non-squamous cell lung cancer to be given a ketogenic diet to limit glucose levels in miceThe results showed that mice fed ketogenic sylloma alone did have some tumor growth inhibition on squamous cell carcinoma, but that such a diet that limited glucose levels had no effect on non-squamous cell carcinomaDr Jung-Whan "Jay" Kim said in response to the results: manipulating host glucose levels, unlike direct attempts to kill cancer cells, may become a new paradigm for activating the body's immune system to track cancer cellsketogenic diet and diabetes drugTo further verify the relationship between blood sugar levels and cancer cell growth, the team selected 192 patients with squamous cell lung cancer and 120 lung adenocarcinoma patients as observational subjects, collected blood samples in random parts, and classified blood samples according to the standard diabetes standard (120 mg / dL blood glucose concentration) researchers found a direct and strong correlation between higher blood sugar concentrations and survival rates in patients with squamous cell carcinoma, while there was no correlation between survival rates in patients with lung adenocarcinoma squamous cell carcinoma (green) and adenocarcinoma (red) In mice fed ketones (left), the growth of squamous cell lung cancer was inhibited, while adenocarcinoma (right) was not affected by diet Photo: University of Texas at Dallas So, researchers again tested mice with squamous cell carcinoma and non-squamous cell carcinoma, feeding them a combination of "ketogenic diet and diabetes drugs." The results of the study prove that this combination therapy is very effective! conclusion
"This is an important observation that further suggests the potential efficacy of glucose restriction in reducing the growth of squamous cell cancer," said Dr Kim, who is excited by the current findings Maybe we can manipulate our own biological system a little bit, or activate what we have in place to fight cancer more effectively but it is worth noting that the effectiveness of this method is currently limited to the type of squamous cell carcinoma and cannot be extended to all types of cancer Dr Kim stressed the need for more comprehensive and detailed clinical studies in the future to validate this new cancer treatment End References: s1 s p63 and SOX2 Bourdain Glucose Reliance and Ii Vulnerabilities in Squamous Cell Carcinomas s.2 s.prnewswire.coms suggests anti-cancer effect of keto diet