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This article is original for Translational Medicine.
Please indicate the source when reprinting.
Author: Sibyl Introduction: Tertiary lymphatic structures usually appear outside the lymphatic system
.
They are rich in immune cells and have similar tectonic functions to structures such as lymph nodes
.
However, we know very little about the reasons for the formation of tertiary lymphoid structures
.
A new study shows that inhibiting the secretion of SATB1 protein in T cells of cancer patients differentiates large numbers of Tfh cells
.
Tfh cells react with B cells to form tertiary lymphoid structures in the tumor, making the tumor develop more slowly, thus prolonging the life of cancer patients
.
Moffitt Cancer Center researchers recently published an article in Immunity titled: "TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures
.
"
The article points out the molecular and cellular mechanisms that control the formation of tertiary lymphoid structures in tumors
.
https://doi.
org/10.
1016/j.
immuni.
2021.
12.
007The human immune system is made up of different types of cells that secrete proteins that affect cancer development, including T cells and B cells
.
T cells are further classified according to their functions and molecular properties: follicular helper T cells (Tfh) and follicular regulatory T cells (Tfr)
.
These different kinds of immune cells interact and influence the development of cancer
.
Tfh cells stimulate B cells to produce antibodies, while Tfr cells inhibit B cell activity
.
They are found in lymph nodes along with other immune cells, and they are also found in tertiary lymphoid structures
.
The study found that patients with tumors of the tertiary lymphoid structure had a better prognosis and a better response to immunotherapy
.
Scientists speculate that immune cells and their secreted proteins in the tertiary lymphoid structure promote the immune system's ability to defend against tumor cells
.
However, this structure is rarely found in mouse model experiments, so the reason for its formation is unknown
.
The researchers conducted a series of experiments to better understand the molecular and cellular mechanisms that lead to the formation of tertiary lymphoid structures
.
By studying cells and mouse models, they found that SATB1 protein plays an important regulatory role in the differentiation of Tfh and Tfr cells
.
SATB1 is a tissue-specific nuclear matrix-binding protein that anchors to specific DNA sequences in a unique cage-like structure and recruits chromatin remodeling factors to regulate gene transcription
.
The researchers found that inhibiting the secretion of SATB1 protein can promote the differentiation of Tfh cells and prevent the formation of Tfr cells
.
They also found some key molecules involved in this process, such as ICOS and TGF-β
.
The researchers verified that mice without SATB1 protein in T cells have a larger proportion of Tfh cells, which can react with B cells to form tertiary lymphoid structures in tumors
.
This also shows the importance of SATB1 in this process
.
They also found that the tumors in the mice injected with Tfh cells developed more slowly compared with the control experiments in which the T cells were injected, which is also closely related to the tertiary lymphoid structure within the tumor
.
The researchers hope their findings can lead to new treatments to control the formation of tertiary lymphoid structures in unresectable tumors and better anti-cancer immunotherapy
.
Dr.
Jose Conejo-Garcia Moffitt Cancer Immunology Research Center director, said: "Approximately 20% of cancer patients have three lymphoid structures
.
Experimental data, we believe that in metastatic tumors and unresectable tumors, autologous Antigenic Tfh cells can promote the formation of tertiary lymphoid structures
.
Anti-tumor T cells in this structure can provide a protective barrier and stimulate immune efficacy to delay the development of advanced malignant tumors, thereby improving the effect of immunotherapy
.
Reference: https :// Note: This article aims to introduce the progress of medical research and cannot be used as a reference for treatment plans
.
If you need health guidance, please go to a regular hospital for treatment
.
Popular·ArticleBasic Research【Science Sub-Journal】Artificial Lung Modification - Lizard Provides Amazing Method! Intestinal flora [Nature] hypoglycemic drugs are ineffective? Because gut microbiota is responsible for cancer treatment [PNAS] Chinese herbal medicines thyme and oregano have discovered anti-cancer compounds Disease diagnosis and treatment [Nature sub-journal] One step closer to changing the $70 billion global diagnostic industry! Protein biosensor measures toxic drugs in cancer, arthritis and organ transplant patients Cardiovascular disease [JAMA Sub] Are you stressed? Stress increases cardiovascular risk! Why do pain and anxiety increase breathing rate? The scientific research "Science" announced the breakthrough in 2021: a problem that has plagued biologists for 50 years was solved by AI and realized the dream of a Nobel Prize winner!
Please indicate the source when reprinting.
Author: Sibyl Introduction: Tertiary lymphatic structures usually appear outside the lymphatic system
.
They are rich in immune cells and have similar tectonic functions to structures such as lymph nodes
.
However, we know very little about the reasons for the formation of tertiary lymphoid structures
.
A new study shows that inhibiting the secretion of SATB1 protein in T cells of cancer patients differentiates large numbers of Tfh cells
.
Tfh cells react with B cells to form tertiary lymphoid structures in the tumor, making the tumor develop more slowly, thus prolonging the life of cancer patients
.
Moffitt Cancer Center researchers recently published an article in Immunity titled: "TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures
.
"
The article points out the molecular and cellular mechanisms that control the formation of tertiary lymphoid structures in tumors
.
https://doi.
org/10.
1016/j.
immuni.
2021.
12.
007The human immune system is made up of different types of cells that secrete proteins that affect cancer development, including T cells and B cells
.
T cells are further classified according to their functions and molecular properties: follicular helper T cells (Tfh) and follicular regulatory T cells (Tfr)
.
These different kinds of immune cells interact and influence the development of cancer
.
Tfh cells stimulate B cells to produce antibodies, while Tfr cells inhibit B cell activity
.
They are found in lymph nodes along with other immune cells, and they are also found in tertiary lymphoid structures
.
The study found that patients with tumors of the tertiary lymphoid structure had a better prognosis and a better response to immunotherapy
.
Scientists speculate that immune cells and their secreted proteins in the tertiary lymphoid structure promote the immune system's ability to defend against tumor cells
.
However, this structure is rarely found in mouse model experiments, so the reason for its formation is unknown
.
The researchers conducted a series of experiments to better understand the molecular and cellular mechanisms that lead to the formation of tertiary lymphoid structures
.
By studying cells and mouse models, they found that SATB1 protein plays an important regulatory role in the differentiation of Tfh and Tfr cells
.
SATB1 is a tissue-specific nuclear matrix-binding protein that anchors to specific DNA sequences in a unique cage-like structure and recruits chromatin remodeling factors to regulate gene transcription
.
The researchers found that inhibiting the secretion of SATB1 protein can promote the differentiation of Tfh cells and prevent the formation of Tfr cells
.
They also found some key molecules involved in this process, such as ICOS and TGF-β
.
The researchers verified that mice without SATB1 protein in T cells have a larger proportion of Tfh cells, which can react with B cells to form tertiary lymphoid structures in tumors
.
This also shows the importance of SATB1 in this process
.
They also found that the tumors in the mice injected with Tfh cells developed more slowly compared with the control experiments in which the T cells were injected, which is also closely related to the tertiary lymphoid structure within the tumor
.
The researchers hope their findings can lead to new treatments to control the formation of tertiary lymphoid structures in unresectable tumors and better anti-cancer immunotherapy
.
Dr.
Jose Conejo-Garcia Moffitt Cancer Immunology Research Center director, said: "Approximately 20% of cancer patients have three lymphoid structures
.
Experimental data, we believe that in metastatic tumors and unresectable tumors, autologous Antigenic Tfh cells can promote the formation of tertiary lymphoid structures
.
Anti-tumor T cells in this structure can provide a protective barrier and stimulate immune efficacy to delay the development of advanced malignant tumors, thereby improving the effect of immunotherapy
.
Reference: https :// Note: This article aims to introduce the progress of medical research and cannot be used as a reference for treatment plans
.
If you need health guidance, please go to a regular hospital for treatment
.
Popular·ArticleBasic Research【Science Sub-Journal】Artificial Lung Modification - Lizard Provides Amazing Method! Intestinal flora [Nature] hypoglycemic drugs are ineffective? Because gut microbiota is responsible for cancer treatment [PNAS] Chinese herbal medicines thyme and oregano have discovered anti-cancer compounds Disease diagnosis and treatment [Nature sub-journal] One step closer to changing the $70 billion global diagnostic industry! Protein biosensor measures toxic drugs in cancer, arthritis and organ transplant patients Cardiovascular disease [JAMA Sub] Are you stressed? Stress increases cardiovascular risk! Why do pain and anxiety increase breathing rate? The scientific research "Science" announced the breakthrough in 2021: a problem that has plagued biologists for 50 years was solved by AI and realized the dream of a Nobel Prize winner!
