Cell Sub-Journal: Simulated fasting can reshape the body's immunity and improve the effect of cancer immunotherapy

Source Clove Academic

At present, immunotherapy has made very positive progress in the treatment of melanoma, lung cancer and colorectal cancer, however, the effectiveness of immunotherapy has so far been limited to specific cancer types, and there are still most patients who are not active in

Over the past decade, the use of some nutrients to simulate fasting, the Fasting Mimicking Diet (FMD), has been beneficial to promote the recovery of the immune system and work synergistically with chemotherapy, radiation therapy, hormone therapy, etc.

On August 23, 2022, a research team from the FIRC Institute of Molecular Oncology in Italy, among others, published a research paper titled Fasting renders immunotherapy effective against low-immunogenic breast cancer while reducing side effects at Cell Reports, demonstrating that fasting simulated diet (FMD) It can enhance the anti-tumor immune response of low immunogenic triple-negative breast cancer (TNBC) and reduce its side effects

Fasting simulated diets can act on the tumor microenvironment, increasing the effects