Cell sub-news confirms the importance of protein for exercise coordination and performance

Researchers at the Karolinska Institute in Sweden have discovered a protein that can improve muscle metabolism, motor coordination and exercise capacity in mice

Muscle health is the main determinant of overall health, and the best way to maintain muscle health is to exercise regularly

In the current study, researchers at the Karolinska Institute wanted to know how a muscle-producing protein called neuroturin affects neuromuscular function

Jorge Ruas, a professor in the Department of Physiology and Pharmacology at the Karolinska Institute, said: "We want to know whether muscles can talk to motor neurons by sending their own messages and find out the consequences of these signals

The researchers found that after genetic modification, the mice that produced more nerves in the muscle cells significantly improved muscle metabolism.

Changed the characteristics of motor neurons

The number of motor neurons in hypernervous Turin mice has also increased.

"In order to discover that a molecule released by muscle fibers can actually change the properties of motor neurons, turning them into a type that is more resistant to degeneration

As a next step, the researchers hope to explore the therapeutic possibilities of Neuro Turin in mouse models of type 2 diabetes, obesity, and ALS

May have therapeutic value

 "There is still a lot of work to be done, but we believe this has therapeutic value for patients with metabolic diseases and neuromuscular diseases (such as type 2 diabetes and ALS)

"Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity" , Jorge C.