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    Home > Medical News > Medical World News > Cell Subs: Stimulating adenosine/A2B receptors can significantly resist aging and increase muscle!

    Cell Subs: Stimulating adenosine/A2B receptors can significantly resist aging and increase muscle!

    • Last Update: 2020-07-23
    • Source: Internet
    • Author: User
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    Aging is associated with decreased metabolism, and metabolic interventions can delay the aging process and increase life expectancyThe main problem in the aging process is the loss of the quality and strength of the skeletal muscle (SKM), a process known as muscle reductionDeclining muscle function leads to energy stabilization and obesity imbalancesAs a result, aging is associated with an increase in obesity, and their independent and parallel development stakes a huge burden on human health and is becoming a major threat to the health of everyone and health systemsOn June 25,, researchers from the University of Bonn in Germany and the University of Eastern Finland in Finland published their latest research on methods to improve aging and obesity in Cellsm, finding that adenosine A2B receptors, expressed in large quantities in skeletal muscle (SKM) and brown fat tissue (BAT), have the potential to fight aging and obesityThe researchers found that A2B was expressed in large numbers in both tissues through gs-paired GPCR analysis of mice SKM and BATAdenosine is an extracellular signaling molecule that transmits signals through four different adenosine receptors (AdoRs) to regulate the physiological function of the tissue: G1-coupled A1 and A3, Gs-coupled A2A and A2B, and stimulates the production of cAMPThe production of CAMP in Adenosine-induced C2C12 cells is eliminated by blocking A2B by specific a2B antagonic PSB603This indicates that the AdoR is highly correlated with the adenosine signaling pathway in SKMIn order to analyze the role of A2B in SKM, the researchers constructed SKM-specific A2B knockout mice (SKMA2B-KO) and found that compared to control, the muscle mass and strength of A2B knockout mice were significantly reduced, the gene expression associated with SKM regeneration was reduced, the level of lipid peroxides associated with aging increased, the aging marker gene increased significantly, and oxygen consumption decreasedConversely, a Combination of A2B agonists Bay 60-6583 to stimulate A2B in older mice significantly increased their muscle mass and strength, causing a significant correction of the indicators and a return to the level of young miceThis suggests that a lack of A2B promotes aging and leads to a decrease in muscle strength and qualityThe researchers then constructed adipose-specific A2B knockout mice (ATA2B-KO) to study the function of A2B in brown adipose tissue and found that bat activity in at-level mice with ATA2B-KO decreased significantly, with a significant reduction in systemic oxygen consumption by 31%, reduced gene expression of the aging markers, increased marker activity of oxidizing stress and lipid peroxide, and reduced expression of vascular cytogenesis and metabolic-related expression genesThe activation of A2B significantly increased the absorption of BAT quantitative standards and increased oxygen consumption by about three times, restoring almost all expressions to levels similar to those in young miceThis suggests that A2B deficiency promotes aging and albinomy of brown fat cells, and A2B stimulation relieves the conditionAnd A2B is mainly through the formation of amorphous adenosine signal conduction, in SKM and BAT play a role Because A2B can affect energy consumption (EE) in mouse SKM and BAT, researchers examined whether A2B stimulation can offset diet-induced obesity findings, pharmacological A2B stimulation can reduce dietary-induced weight gain by affecting body-to-body EE, while significantly increasing muscle mass and strength in mice, and A2B stimulation has no adverse effects on heart rate and blood pressure Finally, the researchers analyzed the role of A2B in human BAT and SKM, and found that the Expression of A2B in human BAT was negatively correlated with age and total fat, and the Expression of A2B in SKM was inversely proportional to aging indicators such as oxygen consumption and oxidation metabolism A2B activation enhances the body's muscle mass, including fiber composition, oxidation metabolism, glucose absorption and utilization, and EE in general, this study provides not only a rational understanding of adenosine receptor interactions and A2B function, but also a potentially valuable way to address issues such as aging and obesity, as well as metabolic diseases .
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

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