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The new coronavirus SARS-CoV-2 appeared at the end of 2019 and caused one of the most devastating global pandemics in modern history
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Similar to other successful respiratory viruses, the high degree of replication of the new coronavirus in the nasopharynx and the shedding of the virus from asymptomatic or symptomatic patients can help enhance transmission and cause rapid community transmission
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Infect
The clinical manifestations of COVID-19 vary greatly-from mild symptoms to long-term and severe disease phenotypes characterized by pneumonia, acute respiratory distress syndrome, and different systemic effects that affect various tissues
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In order to promote effective prevention and treatment of COVID-19 , it is important to distinguish between host protection mechanisms that support rapid virus clearance and limit disease and protection mechanisms that lead to serious and fatal results
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COVID-19 In order to promote effective prevention and treatment of COVID-19, it is crucial to distinguish between host protection mechanisms that support rapid virus clearance and limit disease and protection mechanisms that lead to serious and fatal results.
At present, we still do not fully understand which cells are the main targets of SARS-CoV-2 and how the infection affects respiratory epithelial cells
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Recently, researchers performed single-cell RNA sequencing (scRNA-seq) on nasopharyngeal swabs from 58 healthy people and COVID-19 patients
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During COVID-19, researchers have observed the expansion of the secretory type, the loss of the ciliated type, and the re-proliferation of epithelial cells through the expansion of deoxyribonucleic acid
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In patients with mild/moderate COVID-19, epithelial cells express antiviral/interferon response genes, while cells from patients with severe COVID-19 have a similar viral load, but their antiviral response is not strong
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In patients with mild/moderate COVID-19, epithelial cells express antiviral/interferon response genes, while cells from patients with severe COVID-19 have a similar viral load, but their antiviral response is not strong
The new crown patients with severe local internal SARS-CoV-2 infection in immune compromised force
The new crown patients with severe local internal SARS-CoV-2 infection in immune impaired new crown patients with severe local internal SARS-CoV-2 infection in immune impaired immunitySARS-CoV-2 RNA+ host-target cells are highly heterogeneous, including developing ciliated cells, interferon-responsive ciliated cells, AZGP1-high acinar cells and KRT13+ "hill"-like cells.
The researchers determined that Genes related to susceptibility, resistance, or infection response
Therefore, the study determined the protective and harmful response to SARS-CoV-2, which is the direct viral target of infection, and suggested that the failure of nasal epithelial antiviral immunity may be the basis and precursor of severe COVID-19
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Failure of nasal epithelial antiviral immunity may be the basis and precursor of severe COVID-19
Original source:
Original source:Carly GK Ziegler et al.
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19 .
Carly GK Ziegler et al.
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