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The human immune system starts in the yolk sac (Yolk sac) at 2-3 weeks of fertilization, and hematopoietic stem cells also appear in the embryo's Aorta-Gonad-Mesonephros (AGM, aorta-gonad-mesenephros) area at 3-4 weeks.
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Subsequently, the yolk sac and aortic stem cells migrate to the fetal liver, and the hematopoietic function of the fetal liver reaches its peak at 7-17 weeks and declines at about 20 weeks
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