Cell: the study of vesicles paves the way for innovative treatment of degenerative diseases

February 18, 2020 / BIOON / -- Marina gomzikova, research leader of gene and cell technology laboratory, began to study ecmvs in 2013, when she was studying for her Ph.D Since then, the cells derived from human mesenchymal stem cells (MSCs) have been found to have very promising properties Ecmvs are microstructure surrounded by plasma membrane, which have been proved to be a promising therapeutic tool due to their biocompatibility, miniaturization, safety and regeneration Microbubbles can be used to bypass the existing limitations of cell therapy without losing efficacy At the Federal University of Kazan, researchers are studying cytochalasin B-induced vesicles (cimvs) They are derived from mesenchymal stem cells and are very similar to ecmvs Cell's latest research has studied and characterized the biological activity of MSCs derived cimvs Many bioactive molecules, such as growth factors, cytokines and chemokines, were found in cimvs, and their immunophenotypes were described Most importantly, researchers have found that cimvs stimulate angiogenesis, the growth of blood vessels, just like stem cells Therefore, the team believes that human cimvs MSCs can be used for cell-free treatment of degenerative diseases Cimvs MSCs can induce therapeutic angiogenesis in the treatment of ischemic tissue damage (e.g., ischemic heart disease, hindlimb ischemia, diabetes Vascular disease, and nutritional ulcer), stimulation of the regeneration process in the case of skin injury (trauma and burn), neurodegeneration (multiple sclerosis and Alzheimer's disease), or traumatic injury (peripheral nerve injury and spinal cord injury) Gomzikova's team will continue to explore the potential of artificial microbubbles in the treatment of autoimmune diseases They are also interesting in the use of carrier properties (i.e., the ability of the vesicles to deliver) in the treatment of tumors In conclusion, cimvs can be a new therapeutic tool and a new class of effective and safe drugs for regenerative medicine (BIOON Com) reference: Marina o gomzikova et al Ecological activity of cyclochalasin B-induced membrane vehicles of human mesenchymal stem cells Cells 2020, 9 (1), 95; https://doi.org/10.3390/cells 9010095