CELL: The Wang Xinwei team found that virus exposure characterized the early incidence of liver cancer?

Liver cancer (HCC) is an invasive malignant tumor whose global morbidity and mortality rate continue to rise, but the early detection and monitoring effect is not satisfactoryRecently, using synthetic human viral tumor VirScan, researchers conducted a serological analysis of the history of viral infections in 899 people from NCI-UMD case control studiesThe researchers developed a virus exposure feature and validated the results in a vertical queue of 173 high-risk patients who followed the development of HCC for a long timeThe researchers found a significant correlation between the virus exposure characteristics and the HCC status of high-risk individuals in the validation queue (under the curve: 0.91 at baseline (95% CI 0.87-0.96) and 0.98 (95% CI 0.97-1))This feature identifies cancer patients before clinical diagnosis and is superior to alpha-metaproteinIn summary, the researchers established a virus exposure feature that can predict HCC in high-risk patients before clinical diagnosis, which may be useful for HCC surveillance