Cell: Tsinghua University and Zhejiang University have teamed up to reveal the molecular structure of the new coronavirus.

The new coronavirus SARS-CoV-2, which causes coronavirus disease (COVID-19) in 2019, is now raging around the world.
vaccine is an urgently needed response to control pandemics.
SARS-CoV-2 is associated with two other closely related highly pathogenic viruses, SARS-CoV and MERS-CoV.
SARS-CoV-2 has a just, single-stranded RNA genome of 30kb in size.
its nuclear crust protein (N) is an outer membrane made up of membrane protein (M), envelope protein (E) and hedgehog protein (S), which ensnagends its genome.
photo source: Like SARS-CoV, SARS-CoV-2's S protein binds to their common bind angiotensin conversion enzyme 2 (ACE2) through the bind binding domain (RBD) to mediate the virus into the host cell.
Previously, scientists had confirmed that THES-CoV and MERS-CoV's RBD contained major structural dependence neutrality and supersexuals that could cause strong neutral antibodies in immune animals, thus promising vaccine development targets.
recent progress in the structural clarification of the SARS-CoV-2 protein, the detailed structure of the complete virus has yet to be revealed.
researchers from research institutions such as Tsinghua University and Zhejiang University in China reported on the molecular structure of the real SARS-CoV-2 virus using cryo-electron tomography(cryo-ET) and subtomogram averaging (STA) techniques.
study was published online in the recent cell journal under the title "Molecular architecture of SARS-CoV-2 virus."
the researchers identified the natural structure of the SARS-CoV-2 hedgehog protein before and after fusion, with an average resolution of 8.7 to 11 E.
they analyzed the composition of N-linked glycans in natural SARS-CoV-2 hedgehog proteins using mass spectrometum and found that the overall processing status of these natural N-linked polysaccharies was highly similar to that of recombined SARS-CoV-2 hedgehog proteins.
researchers have revealed the natural composition of the SARS-CoV-2 ribonucleoprotein (RNP) and its high-order assemblies.
Overall, these symptoms reveal in great detail the structure of the SARS-CoV-2 virus and illustrate how the virus wraps its single-segment RNA of about 30 kb in a shell with a diameter of about 80 nm.
: Hangping Yao et al. Molecular architecture of the SARS-CoV-2 virus. Cell, 2020, doi:10.1016/j.cell.2020.09.018.