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The leading academic journal Cell magazine presents a large-scale study of the new coronavirus in the form of a cover paper.
a multinational team found that when cells become infected with the new coronavirus, there are many significant changes.
researchers also found that some drugs could target these changes, potentially leading to the treatment of new coronavirus infections.
in the paper, scientists point out that as a new class of coronaviruses, the new coronavirus has an "asymptomatic infection" that can be contagious before symptoms appear.
We don't know enough about how the virus changes when it infects cells.
for this purpose, the team decided to use mass spectrometry-based quantitative phosphoprotein syntalls to study whether the phosphoric process within the cells affected by the infection of the common cell line.
phosphorylation is a key regulatory step of intracellular signaling pathways.
understanding how proteins from hosts and viruses are phosphorylationd seishaving after infection, hopefully allowing us to understand the pathology of the disease.
, as the researchers predicted, there was a significant increase in phosphorylation of many proteins at different points in time after the virus infected cells.
this includes both proteins from the new coronavirus and host proteins that interact with the new crown virus protein.
based on the dynamics of these phosphorylation sites, the researchers further divided them into five different groups.
interestingly, each group can be hooked on the life cycle of the virus - the first group will rise within 2 hours of infection, associated with the virus entering the cell;
specifically, after infection with the new coronavirus, CK2 and p38 MAPK will be activated, a variety of cytokines will also be produced, and eventually shut down and have filament-related kinases, leading to the cessation of the cell cycle.
, CK2 also promotes the production of fiopular pseudo-foot protrusions, which contain sprite particles.
moment was also recorded by scientists and became the cover of the magazine. What's the use of
to understand these changes in phosphorylation? Based on changes in the activity of the kinase responsible for phosphorylation and known drug action mechanisms, scientists have identified 87 different drugs and compounds that are potentially neo-coronavirus-infected drugs.
of these 87 molecules, 10 have been approved by the U.S. FDA for the market, and 53 are already in clinical trials.
researchers tested the antiviral activity of 68 drugs and compounds and identified strong antiviral potential for CK2, p38 MAPK signaling pathways, PIKEYVE, and CDK inhibitors, making them potential targets for the future.
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