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Authors｜Edited by Wang Cong｜Nagashi Typesetting｜Shuichengwen In modern society, all aspects of work, life and study bring us pressure.
The negative emotions brought by these pressure machines have a great impact on human health.
Previous studies have shown , Stress can cause gray hair, hair loss, obesity, and reduce human immunity, but the specific mechanism by which stress inhibits human immunity is still unclear.
On April 13, 2021, researchers from Western University in Canada published a research paper titled: Chronic stress physically spares but functionally impairs innate-like invariant T cells in the Cell Reports journal.
The study showed that stress-induced hormones (glucocorticoids) can weaken the anti-cancer ability of innate-like T cells, leading to accelerated development and spread of cancer cells.
This study reminds us that the potential of cancer treatment based on congenital T cells will be weakened by human psychological pressure, so the psychological pressure of patients needs to be considered when designing and using these therapies.
Previous studies on the impact of stress on the immune system have often focused on conventional T cells.
So far, no research has explored the impact of stress on innate-like T cells.
Innate-like T cells are heterogeneous T lymphocytes, including constant natural killer T cells (iNKT) and mucosal-associated innate T cells (MAIT).
iNKT cells exist in small amounts in many tissues, but they are especially abundant in omentum tissues between human organs.
However, MAIT cells exist in higher numbers in human peripheral blood, intestines, lungs, liver and other organs.
These innate T cells are the emergency responders of our immune system.
They are in a pre-activated mode and can quickly respond to invading pathogens and cancer cells, just like a loaded gun, ready to make a counterattack at any time.
Previous studies have suggested that when a person suffers from chronic psychological and emotional stress, the body’s immune system will be suppressed, thereby weakening its ability to fight cancer and infections.
This is largely because stress-induced hormones kill Certain immune cells in the human body.
However, this study by Cell Reports shows that congenital T cells do not actually die due to chronic stress, but their anti-cancer ability is greatly impaired by stress-induced hormones (glucocorticoids).
The research team observed that stress-induced hormones damage congenital T cells in a mouse model, which greatly accelerates the development and spread of cancer cells.
This study shows that although innate T cells can stimulate a powerful anti-tumor immune response under the circumstances, their anti-tumor effect fails in the presence of stress.
The corresponding author of the paper, Dr.
Mansour Haeryfar, said that he is currently studying the use of congenital T cells for cancer immunotherapy (iNKT cell therapy).
This study suggests that the cancer treatment potential of congenital T cells will be affected by human psychological stress.
Attenuation, so the psychological pressure of the patient needs to be considered when designing and using these therapies.
In general, this study found that congenital T cells can survive when the individual is under stress, but their anti-cancer function will be impaired, leading to enhanced cancer cell metastasis.
In addition, the study also revealed the specific mechanism by which stress reduces the ability of T cells to fight cancer.
Therefore, these findings can be used to improve cancer immunotherapy based on innate T cells, so that it is still effective for patients with mental stress and stress.
Link to the paper: https://doi.
org/10.
1016/j.
celrep.
2021.
108979 Open for reprint
The negative emotions brought by these pressure machines have a great impact on human health.
Previous studies have shown , Stress can cause gray hair, hair loss, obesity, and reduce human immunity, but the specific mechanism by which stress inhibits human immunity is still unclear.
On April 13, 2021, researchers from Western University in Canada published a research paper titled: Chronic stress physically spares but functionally impairs innate-like invariant T cells in the Cell Reports journal.
The study showed that stress-induced hormones (glucocorticoids) can weaken the anti-cancer ability of innate-like T cells, leading to accelerated development and spread of cancer cells.
This study reminds us that the potential of cancer treatment based on congenital T cells will be weakened by human psychological pressure, so the psychological pressure of patients needs to be considered when designing and using these therapies.
Previous studies on the impact of stress on the immune system have often focused on conventional T cells.
So far, no research has explored the impact of stress on innate-like T cells.
Innate-like T cells are heterogeneous T lymphocytes, including constant natural killer T cells (iNKT) and mucosal-associated innate T cells (MAIT).
iNKT cells exist in small amounts in many tissues, but they are especially abundant in omentum tissues between human organs.
However, MAIT cells exist in higher numbers in human peripheral blood, intestines, lungs, liver and other organs.
These innate T cells are the emergency responders of our immune system.
They are in a pre-activated mode and can quickly respond to invading pathogens and cancer cells, just like a loaded gun, ready to make a counterattack at any time.
Previous studies have suggested that when a person suffers from chronic psychological and emotional stress, the body’s immune system will be suppressed, thereby weakening its ability to fight cancer and infections.
This is largely because stress-induced hormones kill Certain immune cells in the human body.
However, this study by Cell Reports shows that congenital T cells do not actually die due to chronic stress, but their anti-cancer ability is greatly impaired by stress-induced hormones (glucocorticoids).
The research team observed that stress-induced hormones damage congenital T cells in a mouse model, which greatly accelerates the development and spread of cancer cells.
This study shows that although innate T cells can stimulate a powerful anti-tumor immune response under the circumstances, their anti-tumor effect fails in the presence of stress.
The corresponding author of the paper, Dr.
Mansour Haeryfar, said that he is currently studying the use of congenital T cells for cancer immunotherapy (iNKT cell therapy).
This study suggests that the cancer treatment potential of congenital T cells will be affected by human psychological stress.
Attenuation, so the psychological pressure of the patient needs to be considered when designing and using these therapies.
In general, this study found that congenital T cells can survive when the individual is under stress, but their anti-cancer function will be impaired, leading to enhanced cancer cell metastasis.
In addition, the study also revealed the specific mechanism by which stress reduces the ability of T cells to fight cancer.
Therefore, these findings can be used to improve cancer immunotherapy based on innate T cells, so that it is still effective for patients with mental stress and stress.
Link to the paper: https://doi.
org/10.
1016/j.
celrep.
2021.
108979 Open for reprint
