CELL: Why does tumor immunotherapy induce enteritis?
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Last Update: 2020-07-10
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Source: Internet
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Author: User
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Studies have shown that blocking checkpoints with specific antibodies that inhibit receptors from PD-1 and CTLA-4 can induce long-lasting reactions in a variety of human cancersUntil now, however, we still know little about themechanisms ofimmunological causes responsible for severe inflammatory side effectshere, researchers report a comprehensive single-cell analysis of immune cell populations in colitis, a common and serious side effect of checkpoint blockingresearchers observed an alarming build-up of CD8 T cells with high cytotoxicity and proliferation status, with no evidence of regulatory T-cell depletionT-cell receptor (TCR) sequence analysis shows that a significant portion of the CD8 T cells associated with colitis come from tissue-resident cells, which explains why colitis symptoms often appear early after treatment beginsresearchers also found cytokines, chemofactors, and surface receptors that can be used as therapeutic targets for other potential inflammatory side effects blocked by colitis and checkpoints
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