Cells also have another set of "attack and defense system" Cao Xuetao and other first proposed and confirmed anti-viral new epigenetic metabolism mechanism

"We found that cells can also fight viral infections without relying on natural immune methodsCao Xuetao said the virus-host game, as well as the process of interaction, is more complex than has been discoveredHost cells can be used in a variety of ways to resist viral infections, natural immune function to promote interferon production is one of the methods, this way is currently relatively thorough research, but previously on the host cell can not rely on natural immunity to resist the virus by means of unclear understanding, funded by the National Natural Science Foundation Foundation Center Project, the Chinese Academy of Medical sciences and health science and technology innovation project, Cao Xuetao and Liu Yang, Ph.Dstudent in the Department of Immunology of the Institute of Basic Medicine of the Chinese Academy of Medical Sciences, found that RNA demethylase ALKBH5 has a wide range of effects to promote the replication of different types of viruses through biochemical and molecular biotechnology analysisfinally confirmed that once the host cell is infected with the virus, it will inhibit the activity of demethylasease ALKBH5, so that the RNA methylation of the related molecules is enhanced, and then identified and degraded, thereby changing the cell metabolism state and reducing the production of metabolites, and ultimately inhibited viral replicationthis discovery reflects the "inside and outside repair" strategy of the cell's enemy, and puts forward a new view of the host cell's active response to viral infection, and the cross-control mechanism of epigenetic modification and metabolism remodeling to inhibit viral replication.