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Cell’s latest discovery: ruptured cell nucleus promotes cancer cell invasion!

 Last Update: 2021-09-29
 Source: Internet
 Author: User

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outer membrane function

megaspore mother cell

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Image: Image of human tumor cells invading the collagen matrix

Source: Guilherme Nader/Curie Institute

The nucleus has an important function: to protect the DNA of the cell and enable it to be used normally

New research shows that when cells are compressed and the nucleus temporarily ruptures, DNA comes into contact with an enzyme called TREX1 that destroys DNA

In healthy tissues, cells will show signs of aging and stop dividing

These results reveal the importance of TREX1 enzyme in the development and aging process of breast cancer

The main points of the article:

• Deformed nuclei and DNA damage are enriched in breast cancer micro-invasive foci

Article Abstract

(Biocom)

Original search:

Compromised nuclear envelope 1 integrity drives TREX1-dependent DNA damage and tumor cell invasion

DOI

10.

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