Cell's major discovery: Chicken skins can regenerate new hair.

A recent study published in Cell by a Harvard university team of researchers offers hope for "vulture star" hair regeneration, and the study found that chicken skins are a sign that the body promotes hair growthWhen the formation of chicken skins, not only to warm up the body, but also, more importantly, to activate hair follicle stem cells and grow new hair preparation10.1016/j.cell.2020.06.031 Why do we get goose bumps when we're cold or scared? Turns out to be "straight/vertical muscle" (APM) at work! As it appears, APM is the muscle that erects the "sweat hair" and attaches it to the hair follicle bulge area where the hair follicle stem cells (HFSCs) are locatedWhen stimulated by the external environment, the APM, which is dominated by the sympathetic nervous system on the surface of the skin, shrinks and erects hairs in the follicles, while the skin around the pores is "twisted" and looks like "chicken skin"the process of regulating hair follicles Hair growth is closely related to the sympathetic nervous system, and studies have found that sympathetic nerves can regulate formation cells to promote hair growthSo, here's the question: What's the connection between the AFM and the sympathetic nervous system? How does the sympathetic nerve regulate hair growth? What role does a FM play in regulating hair growth? The researchers did a series of experiments to give the corresponding answersFirst, the researchers tested whether the sympathetic nerve selias can regulate hair follicle stem cells (HFSCs)The results showed that increased sympathetic nerve tension promoted the activation of HFSCs, and impaired function of sympathetic nerves dominating other organs made HFSCs more likely to temporarily stop developing (sleepstate)Further studies have found that sympathetic neurosection causes lower levels of norepinephrine in the skin, which can directly regulate HFSCs through Adrb2 (adrenaline receptor)sympathetic nerves directly regulate the development of HFSCs As hair follicle stem cells (HFSCs) are also sensitive to low levels of norepinephrine, which caught the attention of the team, which then studied the cell base of the interaction between sympathetic nerves and HFSCsIt was found that the sympathetic nerves were encased around HFSCs, and interestingly, many sympathetic nerve fibers extended beyond the luminol muscle (APM) and appeared in the hair follicle protrusions and the bristles, which were 'full coverage'intersecting neural networks surrounding HFSCs Finally, the team found that in order to warm the body, the hair muscle (APM) would raise hair to hold back the air, and accelerate activation of hair follicle stem cells (HFSCs) to promote the production of new hairsIt was also found that there was an interaction between the hair follicles and their APM, which is dominated by sympathetic nerves"Therelationship between hair follicles, hair muscles, and sympathetic nerves, said Yulia Shwartz, a postdoctoral researcher at Hsu Labs who is the first author of the studyBut when it's cold, it also lets hair follicle stem cells know it's time to regenerate new hairReferences: "Cell Type Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells .