Central pain control pathways are found.

Why do some people have no problem with needles, and some people are in pain? Researchers at the Center for Neurology and Disease Research, Xi'an Jiaotong University's Frontier Institute of Science and Technology, recently confirmed for the first time that the brain has a direct projection of the sensory regulatory cortex into the spinal cord, participating in the enhanced effect of spinal cord pain information.
at the same time, the effect is not directly related to the brain dry pain control system.
the research, published in the latest issue of Nature Communications.
, xi'an Jiaotong University researchers through the comprehensive use of the body spinal cord all-cell diaphragm clamp records, morphology tracking, immunoscopy and optogenetic technology, such as the discovery of pre-snap back (ACC) presence direct projection to the spinal cord, and directly enhance the spinal cord's excitability sensory information transmission.
ACC may be directly projected onto the spinal cord or mediated through the brain stem to the spinal cord, for the spinal cord sensory information transmission plays a downward easy to regulate in the central nervous system, sensory information from the peripheral nerve sensory endings into the spinal cord, further upward transmission to the sensory cortex.
and motion information comes from the motor cortex, which travels directly to the spinal cord.
previous studies have not found a direct projection of the sensory cortex to the spinal cord.
ACC is part of the edge system and is a nuclear group that is closely related to perception and related emotional and cognitive functions.
this study is of great significance to the internal pain control system, provides a new way of thinking for the downward regulation of spinal cord neurons, and is an important supplement to the previous brain stem-spinal cord downward regulation, especially the regulation of downward adjustment. Professor Zhuo Min, director of the Center for Neurology and Disease Research at Xi'an Jiaotong University in
, said ACC's excitability is increasing in the context of chronic pain, which plays an important role in the maintenance of chronic pain.
if these excitatory saminescability is reduced through genetics and pharmacology, it can have ananalist.
increased ACC excitability leads to increased signals of spinal pain, and patients with pain are more sensitive not only to the brain, but also to the spinal cord.
the further development of this study, it is of great significance to design new treatment sexist and new drugs to control chronic pain in patients in the future.
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