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Binge eating disorder (BED) is a mental illness characterized by repeated overeating (that is, eating an abnormally large amount of food in a discrete period of time, accompanied by a sense of loss of control over eating), but not related to neurological binge eating.
2 2 medsci.
Twenty-seven bedridden adults and 21 weight-matched healthy controls (WMC) completed a multimodal assessment that included resting fMRI scans to measure behavior in reward-based decision-making (i.
In order to provide preliminary data on the clinical relevance of differences in the rsFC group, the study examined the correlation between rsFC and the severity of BED symptoms (the frequency of binge eating days).
Compared with WMC, the rsFC of the striatum seed point in the BED group was lower.
NAcc : ventral caudate nucleus and dorsal caudate nucleus seed point map : the image shows NAcc ( blue ) ( right : x = 12, y = 10, z = −8; left : x = −10, y = 10 , z =−8; ) ventral caudate nucleus ( orange ) ( bilateral, x = ±10, y = 15, z = 0); dorsal caudate nucleus ( red ) ( bilateral, x = ±13, y = 15, z = 9) The seed is used to detect the intensity of rsFC .
NAcc : ventral caudate nucleus and dorsal caudate nucleus seed point map : the image shows NAcc ( blue ) ( right : x = 12, y = 10, z = −8; left : x = −10, y = 10 , z =−8; ) ventral caudate nucleus ( orange ) ( bilateral, x = ±10, y = 15, z = 0); dorsal caudate nucleus ( red ) ( bilateral, x = ±13, y = 15, z = 9) The seed is used to detect the intensity of rsFC .
Differences in the rsFC of NAcc between the two groups: Compared with the BED group, the NAcc of the WMC group had higher rsFC in the following areas (a) left SFG (Brodmann 8, z = 42) and (b) posterior cingulate gyrus (PCG) Brodmann area 23, z = 18).
Differences in the rsFC of NAcc between the two groups: Compared with the BED group, the NAcc of the WMC group had higher rsFC in the following areas (a) left SFG (Brodmann 8, z = 42) and (b) posterior cingulate gyrus (PCG) Brodmann area 23, z = 18).
The difference between the rsFC groups of the seed point of the ventral caudate nucleus: The results showed that the rsFC of the ventral caudate nucleus-left SFG ((a) Brodmann8 area, z = 54; (b) Brodmann9 area, z = 42) was higher in the WMC group.
The difference between the rsFC groups of the seed point of the ventral caudate nucleus: The results showed that the rsFC of the ventral caudate nucleus-left SFG ((a) Brodmann8 area, z = 54; (b) Brodmann9 area, z = 42) was higher in the WMC group.
The seed point of the dorsal caudate nucleus differs between the rsFC groups.
The seed point of the dorsal caudate nucleus differs between the rsFC groups.
NAcc-SFG rsFC is significantly negatively correlated with the inverse learning score.
NAcc-SFG rsFC is significantly negatively correlated with the inverse learning score.
Compared with the WMC group, the rsFC between the ventral side of BED through the dorsal striatum and the frontal lobe was significantly reduced.
In summary, BED is associated with a series of comorbidities of mental illness and the high risk of overweight and obesity, and effective clinical intervention is urgently needed.
The functional organization of the striatum, especially the ventral area, has changed, which is the key mechanism of BED's excessive pursuit of food rewards.
Therefore, interventions aimed at enhancing the fronto-striatal connection and balancing the potential ability to reward consumption drive and executive function are likely to be expected to cure this serious and common eating disorder.
Therefore, interventions aimed at enhancing the fronto-striatal connection and balancing the potential ability to reward consumption drive and executive function are likely to be expected to cure this serious and common eating disorder.
The functional organization of the striatum, especially the ventral area, has changed, which is the key mechanism of BED's excessive pursuit of food rewards.
Therefore, interventions aimed at enhancing the fronto-striatal connection and balancing the potential ability to reward consumption drive and executive function are likely to be expected to cure this serious and common eating disorder.
Original source:
oup.
com/cercor/article-abstract/31/5/2494/6067884?redirectedFrom=fulltext" target="_blank" rel="noopener">Haynos Ann F,Camchong Jazmin,Pearson Carolyn M et al.
Resting State Hypoconnectivity of Reward Networks in Binge Eating Disorder.
[J] .
Cereb Cortex, 2021, 31: 2494-2504.
com/cercor/article-abstract/31/5/2494/6067884?redirectedFrom=fulltext" target="_blank" rel="noopener">Haynos Ann F,Camchong Jazmin,Pearson Carolyn M et al.
Resting State Hypoconnectivity of Reward Networks in Binge Eating Disorder.
[J] .
Cereb Cortex, 2021, 31: 2494-2504.
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