echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Study of Nervous System > Cerebral Cortex: The older the age, the greater the mutation rate of the brain function network

    Cerebral Cortex: The older the age, the greater the mutation rate of the brain function network

    • Last Update: 2021-04-17
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    There are individual differences in brain function and behavior.


    The variability between populations stems from species evolution and gene expression diversity, which is affected by genetic and environmental changes.


    Children's blood vessels

    Based on the resting state fMRI data of the Cambridge Center for Aging and Neuroscience (Cam-CAN) data set, Liying Ma et al.


    They tried to clarify the following points:

    (I) The spatial distribution of IndVar in the functional connection structure observed in healthy adults.


    (II) How does the IndVar mode in the functional network change with age.


    (III) How the distance of brain function connection affects IndVar.


    (IV) The relationship between IndVar and behavioral variability of brain functional connectivity at different ages.


     

    Based on resting state functional magnetic resonance imaging data from a large group of participants (543 adults, 18-88 years old), the functional connectivity of the brain was analyzed to characterize the spatial distribution and differences of individual variability in adult lifespan.


    With the increase of age, the overall difference of IndVar in voxel level.


    With the increase of age, the overall difference of IndVar in voxel level.


    The spatial distribution pattern and variation rate of IndVar voxel levels in the brain .


    The spatial distribution pattern and variation rate of IndVar voxel levels in the brain .


    IndVar shows different trends with age in different functional networks

    IndVar shows different trends with age in different functional networks

    The difference of IndVar with age in different functional networks is further analyzed, the trend is fitted with a quadratic function, and the mutation rate is estimated with a linear function.


     IndVar is affected by functional connection distance

     IndVar is affected by functional connection distance

    The sliding window analysis of the subjects showed that during adulthood (18-88 years old), the number and strength of functional connections increased first and then decreased in the three distance bins, and the inflection point appeared at 47 years old (fitted by a quadratic polynomial).


    The sliding window analysis of the subjects showed that during adulthood (18-88 years old), the number and strength of functional connections increased first and then decreased in the three distance bins, and the inflection point appeared at 47 years old (fitted by a quadratic polynomial).


    In addition, during adulthood, the number or strength of functional connections in the three distance bins is negatively correlated with IndVar, showing a U-shaped trend.


    In the first stage, the difference in cognition and behavior of IndVar is manifested in two modes of change: IndVar in the primary cortex continues to increase with age, but remains at a higher level in the joint cortex .
    In addition, in order to determine the relationship between IndVar's functional connectivity and individual differences in cognitive and behavioral domains, the study combined behavioral data for analysis, including the strength matching test of athletic ability and the fluid intelligence of general advanced cognitive ability (GF )test.
    Force value and age (r(244) = 0.
    67, P  IndVar's cognitive and behavioral differences are manifested in two modes of change: IndVar in the primary cortex continues to increase with age, but remains relatively low in the joint cortex.
    High level

     The study visualized the voxel correlation between IndVar in behavioral differences and functional connectivity.
    The IndVar of the anterior central gyrus, posterior central gyrus, temporal lobe and occipital lobe were positively correlated with the standard deviation of the force value.
    After returning to age, the IndVar of the inferior temporal gyrus (BA20), the temporal pole (BA38) and the top of the inferior frontal gyrus (BA10) were negatively correlated with the standard deviation of the force value.
    However, in the temporal and occipital lobes, the standard deviation of the force value is positively correlated with IndVar.

     

    This study reveals the differences in the functional connectivity of the IndVar model during adult development and aging.
    It is proved that the IndVar of the whole brain function connection increases with age.
    The high-order cerebral cortex always shows high levels of IndVar , and the primary cortex shows increasing levels of IndVar .
    Further analysis shows that IndVar is mainly related to long-distance connectivity in terms of functional connectivity.
    The functionally connected IndVar is significantly related to sports performance.
    Cognitive and behavioral differences between individuals are mainly caused by differences in brain structure and function .
    This study explored the neural basis of IndVar from the perspective of differences in brain functional connectivity at different ages.

    Whole brain functional connectivity of the whole brain functional connectivity IndVar IndVar with age increases, higher-order cerebral cortex consistently demonstrated high levels with age increases, higher-order cerebral cortex consistently demonstrated a high level of IndVar IndVar the primary cortex showed increasing primary cortex showed increasing IndVar IndVar level.
    Further analysis showed that the level.
    Further analysis shows that IndVar IndVar is mainly related to long-distance connectivity in terms of functional connection.
    The functional connection is mainly related to long-distance connectivity.
    Functionally connected IndVar IndVar is significantly related to sports performance.
    Cognitive and behavioral differences between individuals are mainly caused by differences in brain structure and function and are significantly related to sports performance.
    Cognitive and behavioral differences between individuals are mainly caused by differences in brain structure and function

     

    Original source

    oup.
    com/cercor/advance-article/doi/10.
    1093/cercor/bhab059/6210037" target="_blank" rel="noopener">Ma Liying,Tian Lixia,Hu Tianyu et al.
    Development of Individual Variability in Brain Functional Connectivity and Capability across the Adult Lifespan.
    [J] .
    Cereb Cortex, 2021, undefined: undefined.

    oup.
    com/cercor/advance-article/doi/10.
    1093/cercor/bhab059/6210037" target="_blank" rel="noopener">Ma Liying,Tian Lixia,Hu Tianyu et al.
    Development of Individual Variability in Brain Functional Connectivity and Capability across the Adult Lifespan.
    [J] .
    Cereb Cortex, 2021, undefined: undefined.

     



    Leave a message here
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.