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    Home > Active Ingredient News > Study of Nervous System > Certain beta-blockers may reduce Alzheimer's risk

    Certain beta-blockers may reduce Alzheimer's risk

    • Last Update: 2022-06-06
    • Source: Internet
    • Author: User
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    This article is from NEJM Journal Watch (NEJM Journal Watch) Beta-Blockers and Alzheimer Disease Beta-blockers and Alzheimer's Disease Relationship Review Author: Jennifer Rose V.
    Molano, MD Hypertensive patients taking blood-brain barrier permeability comparison The risk of Alzheimer's disease is lower with high beta-blockers than with less penetrant beta-blockers
    .

    Hypertension is a known risk factor for Alzheimer's disease (AD)
    .

    To determine whether beta-blocker use in hypertensive patients is associated with risk of AD, all-cause dementia, and death, the researchers analyzed 69,091 hypertensive patients (median age, 64 years; 65% women) from the Danish National Registry.
    retrospective data
    .

    Of these patients, 24% were taking beta-blockers with low blood-brain barrier (BBB) ​​permeability (atenolol, bisoprolol, and sotalol), and 62% were taking beta-blockers with moderate BBB permeability.
    Beta-blockers (metoprolol), 14% taking beta-blockers with high BBB permeability (carvedilol and propranolol)
    .

    Results at a median follow-up of 9.
    8 years were as follows: patients taking beta-blockers with high BBB permeability had a lower risk of AD than those taking beta-blockers with low BBB permeability (standardized absolute risk difference, -0.
    47%; 95% CI, -0.
    85% to -0.
    10%); in additional sensitivity analyses, the aforementioned lower risk persisted
    .

    Patients taking beta-blockers with low, moderate, or high BBB permeability had a similar risk of developing all-cause dementia
    .

    After adjustment for covariates, including established AD risk factors, patients taking beta-blockers with intermediate or high BBB permeability had a higher risk of death than those taking beta-blockers with low BBB permeability
    .

    The hypothesis put forward by the authors who commented on the study is that beta-blockers with high BBB permeability may improve CSF metabolic clearance in hypertensive patients, thereby reducing AD risk
    .

    They also suggest that the higher risk of death among patients taking beta-blockers with high BBB permeability than in patients taking beta-blockers with low BBB permeability may be due to the fact that this population has unmeasured High comorbidity burden
    .

    The inclusion of AD biomarkers in future studies will help us better understand how beta-blockers affect AD risk in hypertensive patients
    .

    Reviewed article Beaman EE et al.
    Blood–brain barrier permeable β-blockers linked to lower risk of Alzheimer's disease in hypertension.
    Brain 2022 Feb 23; [e-pub].
    (https://doi.
    org/10.
    1093/brain/ awac076) Related Reading NEJM Journal Watch NEJM Journal Watch (NEJM Journal Watch) is published by the NEJM Group.
    It invites internationally renowned doctors to comment on important papers in the medical field and helps doctors understand and apply the latest developments
    .

    "NEJM Frontiers of Medicine" translates several articles every week, publishes them on the app and official website, and selects 2-3 articles and publishes them on WeChat
    .

    Copyright Information This article was translated, written or commissioned by the NEJM Frontiers in Medicine, jointly created by Jiahui Medical Research and Education Group (J-Med) and The New England Journal of Medicine (NEJM)
    .

    The full text of the Chinese translation and the included figures are exclusively authorized by the NEJM Group
    .

    If you want to reprint, please leave a message or contact nejmqianyan@nejmqianyan.
    cn
    .

    Unauthorized translation is an infringement, and the copyright owner reserves the right to pursue legal responsibility
    .

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