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The relationship between the virus and the organism's microecology is mutual, and both are in a highly dynamic process of change.
A study jointly completed by Professor Ma Shengli, Director of the Oral Microecological Technology Innovation Center of Heilongjiang Province, and Professor Huang Zhiwei from the School of Life Sciences of Harbin Institute of Technology, and others showed that: the new crown virus infection changes the composition of the oropharyngeal microbiota, resulting in local microbiota The disorder causes the oral pathogens to translocate into the lungs, which eventually leads to concurrent lung infections.
Many studies have confirmed that in this new crown pneumonia epidemic, entering the human body through the oropharyngeal cavity is the most important way for the new crown virus to invade; and the oropharynx, as the entrance to the respiratory and digestive tracts, is the first line of defense for human health.
With the support of the Heilongjiang Provincial Department of Science and Technology Application Technology R&D project, Ma Shengli’s team quickly carried out closed-loop scientific research and epidemic research on multiple levels in the micro-ecological field, including going to designated hospitals to collect throat swab samples from patients with new crowns, and through the oropharyngeal micro Ecological metagenomic testing, looking for the internal connection between the new coronavirus infection and the micro-ecology, and determining the relevant factors of the new coronavirus infection; obtaining the characteristic flora, genes and metabolites related to the new coronavirus infection, and constructing the risk assessment of the new coronavirus infection The system is used to guide the risk prevention and control of the new coronavirus; based on the research results and the principles of microecology, a rapid detection platform for micro-droplets and microfluidics in the oropharynx is established to achieve rapid screening of new coronavirus infections among the normal population, and hospitals Detection "port forward"; optimize the existing nucleic acid detection experiment process, improve detection capabilities, and implement the closed-loop system of nucleic acid detection and risk prevention and control in the hospital under the new normal.
Through metagenomic sequencing, Ma Shengli's team obtained the characteristic bacterial flora of the pharynx of the new crown disease population, such as the conditional pathogenic bacteria Weirionella and Macrococcus, as well as Pseudopropioni and Rossella.
The research team also found that the proportions of certain bacterial groups such as Klebsiella, Acinetobacter and Serratia are positively correlated with the severity of the patient’s new coronavirus infection and systemic inflammation markers, suggesting changes in these oropharyngeal microbiota It may affect the condition of patients with new coronary pneumonia by interfering with the inflammatory response.
In addition, Ma Shengli's team also observed that the oropharyngeal microbiome of patients with new coronary pneumonia is significantly enriched in amino acid metabolism and heterologous biodegradation and metabolism.
The Ma Shengli team actively carried out medical-industrial cross-cooperation based on the changes in the human microecology, and developed the "New Coronavirus Rapid Detection Platform".
Expert evaluation pointed out that the microbial barrier of the oral, nasopharyngeal cavity is the first barrier for viruses and bacteria to invade the human body.