Changes in plasma glycophospholipids in patients with Movement Disordres-Parkinson's disease are not associated with glucosylglycerol levels

Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide

Figure 1: Paper cover image

Decreased GCase activity has been described in the brain tissue of PD patients with and without GBA1 mutations, and in healthy aging subjects, but a recent study showed no association between total GCase activity and PD risk sex

Hereby, Danielle te Vruchte et al.

They analyzed plasma GSLs and glucoglyceramide (GlcCer) using two normal-phase high-performance liquid chromatography methods; extracting clinical demographic data

Figure 2: The results of the paper

They analyzed 80 PD subjects and 25 HCs

PD patients had higher levels of GlcCer, GD1b, Gb4, GalNAcGA1, and series b than HCs; PD patients had lower levels of total GSLs, GT1b, GM1a, GM3, GM2, and series a than HCs

Results were similar after excluding some GBA1 mutation carriers

The significance of this study lies in the discovery that multiple GSL abnormalities in plasma were detected in patients with and without changes in GlcCer, suggesting a broader shift in lipid homeostasis

Original source:

te Vruchte D, Sturchio A, Priestman DA, et al.