Changes in serum lipoprotein concentration seis isoproteins associated with increased aSAH risk

Ref: Lindbohm J, et alAtherosclerosis2018 Jul;274:112-119doi: 10.1016/j.atherosclerosis.2018.05.011Epub 2018 May 5.)abnormal blood lipid levels are risk factors for cardiovascular diseasePrevious studies on the relationship between blood lipid levels and aneurysm-based cobweb subcavity bleeding (aSAH) have focused on the effects of serum total cholesterol (total cholesterol, TC), but the conclusions are controversial, with reports of elevated TC levels as aSAH risk factors, and also that reduced TC levels are aSAH risk factors or both have no statistical correlationOther components of lipids, such as hdiaprotein (HDL-C) and low-density lipoprotein (LDL-C), have had few prospective studies on the relationship between lipoprotein A1 (ApoA1) and lipoprotein B (ApoB) and aSAHJoni Lindbohm of the School of Public Health at the University of Helsinki in Finland, who studied the relationship between serum lipid concentrations and aSAH, was published online in May 2018 in Atherosclerosisthis prospective, large sample-based population study, data was provided by the Finnish National FINRISK Research Project on 65,521 participants between 1972 and 2007The study participants were measured in blood pressure, height and weight, took a blood sample of a semi-empty stomach after at least 4 hours of fasting to detect cholesterol and lipoprotein concentrations, and used structured questionnaires to collect data on smoking, alcohol consumption and socioeconomic statusPatients have been followed since they entered the group and recorded the final follow-up results on 31 December 2014, including aSAH, immigration or deathThe hospital's discharge registration and death registration form records the occurrence of all deaths (including deaths outside the hospital) or non-fatal aSAHDeaths due to aSAH outside the hospital, in the hospital or in the emergency room are classified as sudden deathsThe cause of sudden death in aSAH can be further diagnosed in an autopsy and, if necessary, examined by a professional disease classifier and determines the root cause of deathThe value of ApoA1, ApoB and LDL-C were used to predict the value of aPoA1, ApoB and LDL-C risk using the Cox scale risk model2014, 543 patients were found to have been hospitalized or died as aSAH in 1.52 million follow-up visitsFor every additional standard deviation concentration (1.28 mmol/l) of TC, the male aSAH risk increased by 1.15 times (95% CI, 1.00-1.32)For every reduction in HDL-C standard deviation concentration (0.37mmol/l), the female aSAH risk increased by 1.29 times (95% CI, 1.07-1.55) and the male aSAH risk increased by 1.20 times (95% CI, 1.14-1.27)Increased apoA1 concentration was associated with a reduction in aSAH risk: for every additional standard deviation concentration (0.29g/l), the male aSAH risk decreased (HR-0.88; 95% CI, 0.76-1.02), and the female aSAH risk decreased (HR.85; 95% CI, 0.74-0.97)For every additional standard deviation concentration (1.07mmol/l) of LDL-C, the risk of aSAH increased by 1.15 times (95% CI, 1.01-1.31); Age does not affect the risk of aSAHconcluding that high or too low blood lipid concentrations can contribute to an increased risk of aSAH, especially in men, and that the effects of different blood lipid components are not consistentWhether statins can reduce the risk of aSAH remains to be seen(
Fucompiled, Liu Chenghong,of the First People's Hospital in Changshu City, Jiangsu Province,review, editor-in-chief of "Outside Information" and editor-in-chief of Huashan Hospital, affiliated with Fudan University,Chen Quancheng)related links