Chem. Commun.: new CD MOFs materials deliver drugs effectively

As a kind of multifunctional organic-inorganic hybrid crystal material, metal organic framework (MOFs) has shown its various functions in many research fields, such as gas storage, separation, luminescence, sensor and so on In recent years, the development and expansion of MOF materials in the field of drug loading has become a research hotspot CD MOFs with cyclodextrin as the organic ligand and potassium ion as the inorganic metal center is a new drug carrier with high safety Its particle size is controllable, its function is diverse, and it has good biocompatibility It has important application value in the field of drug delivery However, CD MOFs disintegrates rapidly when encountering water, which limits its application The existing strategies to increase the stability of CD MOFs in water take a long time and reduce the drug loading capacity of CD MOFs Therefore, it is still a great challenge to synthesize stable porous CD MOFs Cholesterol surface modified cd-mof can significantly improve its stability in water (source: Chemical Communications) A team composed of Shanghai Institute of medicine, Paris Sud University of France, Jilin University and Sun Yat sen University invented a fast and mild method to significantly improve the stability of CD MOFs in water and overcome the lack of poor stability of CD MOFs in water Researchers grafted cholesterol molecules onto CD MOFs by simple and efficient methods, forming a protective hydrophobic shell on the surface of CD MOFs, which significantly improved the stability of CD MOFs in water, that is, cholesterol modified CD MOFs (cd-mof-chs) The cholesterol modified CD MOFs (CD MOFs CHS) can maintain its internal crystalline structure and complete external morphology 24 hours after contact with water Cd-mof-chs nanoparticles can significantly improve the uptake of doxorubicin in HeLa cells and effectively deliver drugs In vivo pharmacokinetic study showed that the half-life and area under curve (AUC) of adriamycin loaded nanoparticles on cd-mof-chs were significantly increased.