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    Home > Biochemistry News > Biotechnology News > Chem. Soc. Rev. Li Jia's team from Shanghai Institute of Medicine published a "Guideline Review" for the research of small molecule fluorescent probes

    Chem. Soc. Rev. Li Jia's team from Shanghai Institute of Medicine published a "Guideline Review" for the research of small molecule fluorescent probes

    • Last Update: 2021-07-30
    • Source: Internet
    • Author: User
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      On July 7, 2021, Li Jia's team from Shanghai Institute of Materia Medica, Chinese Academy of Sciences, team from East China University of Science and Technology He Xiaopeng, Tony D.
    James from the University of Bath, and Jonathan L.
    Sessler from the University of Texas at Austin, jointly wrote The "Tutorial Review" article titled "Small-molecule fluorescence-based probes for interrogating major organ diseases" summarizes the classification of small-molecule fluorescent probes that can be used to detect major organ diseases

    .
    Related results were published online in
    Chemical Society Reviews, an authoritative review academic journal
    .
      The human body is an organism composed of multiple organ systems.
    Each organ plays a specific role in the body, and the coordinated work between the organs maintains the normal operation of the human body

    .
    However, abnormal organ dysfunction can affect the health of the body and lead to catastrophic consequences

    .
    The development of identification technologies such as omics has prompted the discovery of biomarkers related to organ dysfunction

    .
    The development of non-invasive methods that can observe the biomarkers of specific organ diseases in real time will improve the ability to study pathological changes of specific organs and facilitate the early diagnosis of diseases, thereby providing help for the development of effective treatment methods

    .
      Fluorescence bioimaging-based detection technology is used in the detection of disease biomarkers due to its high sensitivity, simple operation, low detection limit, fast response speed, excellent temporal and spatial resolution, and non-destructive in-situ imaging in vivo.
    It is an organ disease.
    The diagnosis provides a more reliable basis

    .
      Based on the above background and the team's preliminary research foundation, in this review, researchers have classified and summarized the small molecule fluorescent probes that can be used to detect major organ diseases
    .
    This article mainly introduces the design strategy of small molecule fluorescent probes for the research of major organ diseases, and emphasizes the importance of biomarker detection for the study of organ dysfunction and other organ-related diseases

    .
    In addition, the article introduced in more detail the use of small molecule fluorescent probes to monitor various pathogenic processes in vitro and in vivo

    .
    Finally, the research team focused on the limitations of small-molecule fluorescent probes currently used to study organ diseases, and put forward corresponding suggestions and prospects

    .
    This review has important reference significance for the development of new and effective fluorescent molecular probes for early diagnosis and treatment of diseases of different organs

    .
      East China University Dr.
    Han Haihao
    first author (drugs reach Rick linked training graduates) based papers, Gilbert researcher, Professor He Xiaopeng, Professor Tony D.
    James
    and Professor Jonathan L.
    Sessler
    oriented co-corresponding author of the paper
    .
    Researcher Zang Yi from Shanghai Institute of Materia Medica, Dr.
    Adam C.
    Sedgwick from the
    University of Texas at Austin, and Dr.
    Tian He from East China University of Science and Technology contributed to the completion of this paper
    .
    This work has been funded by the National Natural Science Foundation of China, the Major Research Program of Shanghai Science and Technology, the Shanghai International Cooperation and Exchange Program, and the general funding of the China Postdoctoral Science Foundation

    .
    Figure 2: a) Schematic diagram of the main human organs involved in this review and b) Schematic diagram of the design strategy of small molecule fluorescent probes for detecting organ-related diseases
      (Contributor: Li Jia's research group; Contributor: Li Jia's research group)
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