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    Home > Food News > Nutrition News > Chemists developed cholesterol testing systems

    Chemists developed cholesterol testing systems

    • Last Update: 2022-11-14
    • Source: Internet
    • Author: User
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    Image: A microfluidic chip that integrates all elements of the system is printed on a
    3D printer.

    Image credit: Rodion Narudinov/UrFU

    Scientists at Ural Federal University (UrFU) have developed a new sensor device for determining the level
    of cholesterol in the blood.
    The system does not use protein compounds, i.
    Chemists replaced them
    with an inorganic analogue, copper chloride.
    This makes the process of making a cholesterol meter cheaper and makes blood testing easier, faster, and easier

    "The determination of cholesterol currently uses colorimetry, chromatography and enzymes
    However, these methods either use extremely aggressive reagents, use complex and expensive equipment, or extract biomolecules from living organisms as sensitive elements – enzymes
    – that recognize and determine cholesterol levels.
    For example, certain species of bacteria produce cholesterol oxidase
    In addition, enzymes are natural polymers, proteins, therefore, they are easily denatured, requiring certain storage conditions, temperature and acidity regimes
    We decided to choose a non-biological analogue of this enzyme to make the cholesterol analysis process cheaper, easier, and faster
    One of the most affordable options is copper chloride, which we first found to be highly sensitive to cholesterol," explains
    Andrei Okhokhonin, associate professor at the Department of Analytical Chemistry at the University of Urfur.

    With this new device to measure cholesterol levels, a small amount of blood is sufficient
    The blood is placed in
    an analytical chip containing a solution of copper chloride and acetonitrile.
    An electrode is integrated into the chip that is connected
    to a voltammetric analyzer that gives the analysis results.
    The new chip for analyzing cholesterol levels also has the advantage of containing magnetic nanoparticles, polymers with molecular imprints that selectively absorb cholesterol and screen out any other signature substances
    that make up the blood.

    "Molecularly imprinted polymers need to efficiently separate
    cholesterol from other substances in the blood.
    After a variety of choices, we chose ethylene glycol dimethacrylate as the crosslinker and vinylpyridine as the functional monomer
    Polymers synthesized on the surface of magnetic nanoparticles effectively adsorb cholesterol, so we can talk about high selectivity for the analysis, since there is no interference from other substances," emphasizes Andrei Okhokhonin

    The microfluidic chip that integrates all the elements of the system is printed on a 3D printer, which also facilitates the production process of the device and makes it faster
    The scientists noted that the first tests they conducted were not on biological samples, but on
    model solutions that simulated serum.
    The next stage of the researchers' work is to test the system
    on real blood samples.

    For several years, scientists have been researching and developing enzyme-free sensors for the determination of many important biological substances such as glucose, urea, creatinine, and others
    Alcohol detection

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