Chen Caiyong's team from the Academy of Biological Sciences published an article on Blood to reveal an important regulatory mechanism for iron metabolism in red blood cells

Red blood cells are the most abundant types of cells in the human body, and they need to absorb large amounts of iron ions during maturation for the synthesis of heme and hemoglobin

On September 8, 2022, Chen Caiyong's team from the School of Life Sciences of Zhejiang University published a paper "Grab regulates transferrin receptor recycling and iron uptake in developing erythroblasts" in the international authoritative journal Blood, revealing the important mechanism

Through the study of mammalian erythroblastic cells and primary erythrocytes, the team found that the loss of Grab slows Tfrc recovery and iron absorption, causing disorders

Pattern diagram of Grab's regulation of the red blood cell transferrin cycle

In recent years, genome-wide association studies (GWAS) have shown a significant correlation

Chen Mengying, Zhang Yuhan and Karen Jiang, graduate students in the laboratory of Chen Caiyong, College of Life Sciences, Zhejiang University, are the co-first authors of the paper, and Professor Chen Caiyong is the corresponding author

Original link: https://ashpublications.