Chen Jianfeng's group collaborated to discover a new mechanism by which different chemokines regulate the binding of integrin α4β7 to HIV-1 virus

After HIV (Human immunodeficiency virus, HIV) -1 virus infects the human host, it replicates in large amounts in Gut-associated lymphoid tissue (GALT), and infects CD4 ⁺ T cells to gradually deplete it, triggering acquired Acquired immune deficiency syndrome (Acquired immune deficiency syndrome, AIDS)

Chen Jianfeng's team found that inactive integrin α4β7 cannot bind to gp120, and only when integrin α4β7 is highly activated can it bind to gp120

In summary, this study reveals that specific chemokines in the intestine can promote the binding of α4β7 and HIV-1 virus gp120 by causing a specific activation conformation of integrin α4β7, and activate multiple intracellular signaling pathways, ultimately promoting HIV -1 infection of T cells

Researcher Chen Jianfeng from the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences is the corresponding author, researcher Li Guohui and Associate Researcher Zhang Yuebin from Dalian Institute of Chemical Physics, Chinese Academy of Sciences are the co-corresponding authors, and Dr.

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