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    Home > Biochemistry News > Biotechnology News > Chen Lihan's research group published an article in Chemical Senses to show that the application of trigeminal nerve mixed olfactory agent stimulation to the human nostrils can induce perceptual bias in sound position

    Chen Lihan's research group published an article in Chemical Senses to show that the application of trigeminal nerve mixed olfactory agent stimulation to the human nostrils can induce perceptual bias in sound position

    • Last Update: 2022-11-14
    • Source: Internet
    • Author: User
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    For a long time, the nasal chemical senses have been considered unimportant senses, and it has even been suggested that the information people get through smell is insignificant, and the use of smell is considered to be a substitute for losing other senses
    However, in fact, the sense of smell plays a vital role
    in human life.
    In daily life, smell information "guides" our behavior, affects our feeding behavior, prompts dangerous information about the external environment, helps us locate and navigate, and promotes people's social communication

    For spatial positioning navigation, humans do not rely entirely on a single sensory information, although people are considered visual navigators, but in fact humans can use arbitrary sensory information to evaluate the target position
    in space.
    Therefore, although people will give preference to visual information in spatial navigation or spatial positioning, information input from other senses will also affect the final navigation or positioning results

    The Ventriloquist effect was originally used to describe the effect
    of visual information affecting auditory position perception.
    In this study, the authors used the highly sensitive paradigm of abdominal language effect to investigate whether unilateral odor input affects participants' perception of sound position
    The study recruited 41 participants (15 males and 26 females, aged 22.
    6 ± 3.
    2 years) who passed the Chinese olfactory recognition test, and the odor stimulation was stimulated by 10% volume fraction phenylethanol (only activates the nasal olfactory nerve pathway), 1% volume fraction menthol (activates both the nasal olfactory pathway and the intranasal trigeminal nerve pathway) and propylene glycol (control group and solvent).

    。 During the experiment, the participants would hear a pure tone lasting 1.
    5s during the inhalation stage (odor input on one side, control group on the other side), and the position information of the sound was simulated by the head transfer function, and the sound position angles were 20°, -10°, -5° and the center on both sides, with a distance of 1m
    Participants were tasked with determining whether sounds appeared on the left or right and reporting their confidence in making judgments (Figure 1).

    The data were combined by the Sigmoid function to calculate PSE, and the results showed that the one-sided phenethanol input did not affect the participant's judgment of the direction of the sound, but the one-sided menthol input would bias the position of the perceived sound to the direction of
    the odor.
    Based on this result, the authors speculate that if and only if odor stimulates the intranasal trigeminal nervous system, the perception of sound position can be systematically shifted
    This study extends the multisensory abdominal language effect from non-chemical sensory pathways to chemical sensory channels, and suggests that the neural properties of odor itself (pure olfactory odor or olfactory trigeminal mixed odor) may play a role
    in odor abdominal language effects.

    Figure 1.
    An experimental paradigm for sound localization
    Participants heard sounds
    while inhaling odors.
    The sound orientation is defined as the angle at which it is deflected from the sagittal plane of the head ('-' means to the left, '+' means to the right).

    ITI: length of test interval; Determining the direction: left or right
    Confidence level: From 1 to 7 (1 means "just guessing" and 7 means "very confident"
    ) The higher the score, the more confident you are).

    Figure 2.
    Unilateral odor flows into the PSE shift
    in the perception of sound direction.
    (a,b) Psychophysical curves
    of sound direction judgment under different odor-odor stimuli nostril conditions (control, left phenylethanol, right phenethanol, left menthol, right menthol).
    Negative values on the horizontal axis indicate left sound stimuli, and positive values on the horizontal axis indicate right sound stimuli
    (c,d) Individual PSE values
    under different odor-odor-nostril irritation conditions.
    The middle dot and two arrows represent an individual
    The input of one-sided menthol leads to a systematic deviation in the direction of perceived sound, moving
    towards odors.
    (e,f) PSE offset
    of individual data.
    Error bars refer to SEM, **p < 0.

    Liang Kun, a doctoral student in the research group of Associate Professor Chen Lihan of the School of Psychology and Cognitive Science, Peking University, is the first author of this paper, postdoctoral fellow Wang Wu and postdoctoral Gong Wenxiao, doctoral student Zeng Huanke and doctoral student Lou Chunmiao, and Lei Xiao, doctoral student of the Institute of Advanced Interdisciplinary Science, Peking University, participated in the research, and Associate Professor Chen Lihan is the corresponding author
    of this paper.
    The research was supported
    by the National Natural Science Foundation of China International (Regional) Cooperation and Exchange Program - Sino-German Interdisciplinary Major Cooperation Research Project and Science and Technology Innovation 2030 - Brain Science and Brain-like Research Major Project.

    Liang, K.
    , Wang, W.
    , Lei, X.
    , Zeng, H.
    , Gong, W.
    , Lou, C.
    , & Chen, L.
    Odor-induced sound localization bias under unilateral intranasal trigeminal stimulation.
    Chemical Senses, 47,1-8 https://doi.

    PI and research group introduction

    Associate Professor Chen received his Bachelor of Engineering degree (Zhejiang University) in 1999, his Master of Education (Zhejiang University) in 2005 and his Doctor of Philosophy degree (University of Munich)
    in 2010.
    Since 2019, he has been the deputy dean
    of the Department of Brain and Cognitive Science, School of Psychology and Cognitive Science, Peking University.
    Member of Chinese Psychological Society, Member of Engineering Psychology Professional Committee of Chinese Psychological Society (2016-present), Member of Scientific Committee of International Multisensory Channel Research Forum (2016-present), Vice Chairman of Cognitive Modeling Professional Committee of Chinese Cognitive Science Society (2021-2025), Member of Human Factors and Ergonomics Branch of Complex Systems of Chinese Ergonomics Society (2021-2025), Expert member of the User Experience Standards Working Committee of China Electronics Industry Standardization Technology Association (2022-present), and expert member of the China Sensory Analysis Standardization Technical Committee (2022-present).

    Editorial Board Member of Perception (2021-2024), Editorial Board Member of Frontiers in Virtual Reality (2019-present).

    His research interests are multisensory channel time perception; Stimulation coding and feature association across sensory channels; tactile perception; Engineering Psychology and Human

    Lab homepage: https://multisensorylab.


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