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Researcher
Chen Yihua’s research group has been committed to the biosynthesis of microbial natural products and synthetic biology.
On the basis of revealing and understanding the unique biosynthetic mechanism of different natural products, the concept of synthetic biology is used to design and transform to obtain more new structures.
Figure 1 : The biosynthesis of the starting polyketide ART for methyl esterification on-line modification
Polyketone natural products are an important part of microbial natural products, which have good medicinal value and other important physiological functions
.
Compound Aurantinin ( ART ) is a unique class of 6/7/8/5 polyene tetracyclic polyketides complex structure, in this study the authors first identified ART biosynthetic gene cluster compound and by analyzing ART structure different The formation of methyl groups studied the assembly process of its polyketone chains
Figure 2 : On-line modification initiation method of polyketides
Nian 2021 7 Yue 23 International Day authoritative journal integrated " Nature Communications " Online published a report entitled " Initiating Polyketide biosynthesis by ON-Line methyl Esterification " research articles, we reported the online novel way of starting methyl polyketide Biosynthesis of similar compounds
.
Institute of Microbiology, Chinese Academy of Sciences Research Associate Li Pengwei first author for the paper, Chen Yihua researcher for the corresponding author
Article link: https:// align="justify">