echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Chen Yiyun, research group of Shanghai Institute of organic chemistry, Chinese Academy of Sciences, made progress in the field of photocatalytic biocompatibility in living cells

    Chen Yiyun, research group of Shanghai Institute of organic chemistry, Chinese Academy of Sciences, made progress in the field of photocatalytic biocompatibility in living cells

    • Last Update: 2019-01-17
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com
    The real-time regulation of cell life activities is of great value to the study of cell physiological functions Light has excellent spatiotemporal resolution, and biocompatible photoinduced chemical tools can be used to control dynamic life processes in situ and in real time In recent years, the development of the traditional method of photocage removal hopes to achieve the following important new characteristics: first, through cheap and easily available visible light source to achieve better biological penetration; second, the substrate has light stability so that it does not need to be prepared on the spot; third, the specific photocage can be located Compared with the direct light irradiation method, the photocatalytic oxidation-reduction reaction uses low energy visible light, and the substrate is inert to light when there is no photocatalyst, so it is easy to store However, there are some difficulties in the application of photocatalytic redox reaction in cells: 1 Transition metal photocatalyst has potential toxicity of cell metabolism, which will limit its application; 2 Oxygen and various antioxidants widely existing in cells will affect the life span of free radical active species and the efficiency of photocatalytic redox reaction Chen Yiyun, research group of State Key Laboratory of life organic chemistry, Shanghai Institute of organic chemistry, Chinese Academy of Sciences, is committed to the development of new methods of Biophase volume photochemistry for chemical and biological research The main research contents include: the discovery of new types of photochemical reactions and the development of new types of photochemical biological tools Recently, Chen Yiyun's research group and Xu Tianle's research group of Shanghai Jiaotong University School of Medicine reported for the first time that fluorescein or rhodamine derivatives, which are commonly used in fluorescence imaging, are used as biocompatible photocatalysts to generate hydrogen peroxide in cells through photocatalytic oxidation-reduction reaction using oxygen and antioxidants, and then to carry out the debonding hydroxylation reaction To release bioactive molecules The related results were published on angew Chem Int ed (DOI: 10.1002/anie.201811261) The first author of this paper is Wang Haoyan, a doctoral candidate of Shanghai Institute of organic sciences In this reaction, CFL or low-energy blue LED lamp are used as the light source In the neutral aqueous solution, the biologically active molecules containing phenol, hydroxyl and amino groups can be released efficiently In this method, the protein expression in E Finally, the team used rhodamine derivative dye as a photocatalyst with localization effect, and realized the subcellular localization selective small molecule visible light cage removal with the help of the limited free diffusion of hydrogen peroxide in the cell This study shows the broad application prospect of photocatalytic oxidation-reduction reaction in cell and life system research, and proposes that organic fluorescent dyes have dual functions of tracking and regulating life process, which has important enlightenment for the research of related fields                           .
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.