Chen Yu and Shi Jianlin from Silicate Institute of Chinese Academy of Sciences published a review in Chem SOC Rev: nano catalytic chemical reaction for tumor specific treatment

Recently, researcher Chen Yu and researcher Shi Jianlin from Shanghai Silicate Research Institute of Chinese Academy of Sciences were in the review of Chemical Society of Royal Chemical Society In this paper, we summarize a series of recent research progress of specific in-situ chemical reactions in tumor internal triggered by endogenous tumor microenvironment or exogenous physical irradiation, so as to achieve the purpose of cancer treatment, and discuss in detail the challenges and development direction of this frontier research field in the future Nanoparticle triggered in situ catalytic chemical reactions for tumour specific therapy Han Lin, Yu Chen * and Jianlin Shi * chem SOC Rev., 2018, advance article doi: 10.1039/c7cs00471k thank researcher Chen Yu for his careful review and modification of this report "Nano catalysis medicine" cancer is one of the few diseases that can not be conquered by modern medicine Cancer cells bring great difficulties to the treatment of cancer due to their complex and diverse metabolism and ecological micro environment In the current cancer treatment strategy, chemotherapy is still one of the most commonly used means However, conventional cancer chemotherapy, when the highly toxic drugs act on the whole body and cause strong side effects, the efficacy of the focus is greatly reduced In fact, strong side effects and low chemotherapy effect have become one of the main causes of death for cancer patients Therefore, it is very important to develop a non-toxic, safe and efficient cancer treatment system The team of researcher Shi Jianlin and researcher Chen Yu from Shanghai Silicate Research Institute of Chinese Academy of Sciences put forward a new cancer treatment strategy of "nano catalysis medicine" In order to selectively kill tumor cells without toxic side effects on normal tissues, safe and non-toxic drugs can be transformed into toxic substances in situ under the stimulation of tumor microenvironment by multiple, highly selective and highly specific catalytic reactions ▲ god-fe ₃ o ₄ @ dmsns nano catalyst is targeted to gather in tumor tissue, and hydroxyl radicals generated after continuous biocatalysis and chemical catalysis can kill cancer cell NAT Commun., 2017, 8, 357 Using this research strategy, the team carried out a series of cutting-edge exploration work of non-toxic and side-effect tumor chemotherapy, and achieved remarkable results For example, the dendrimer mesoporous silica nanoparticles were used as the drug delivery system carrier, and then loaded with ultra-small Fe3O4 nanoparticles and glucose oxidase with a diameter of 2 nm in turn to build a new nano catalyst The catalyst uses the vigorous glucose raw materials and the micro acid metabolism environment in tumor cells to carry out a chain and efficient catalytic reaction The highly toxic hydroxyl radicals can induce the apoptosis of tumor cells, and will not cause damage to normal tissues and organs (NAT Commun., 2017, 8, 357); using mesoporous silica nanoparticles as the carrier, the nontoxic metalloporphyrin molecules are transported to cancer focus Under the effect of conventional ultrasound field, a large number of singlet oxygen radicals are generated in the tumor, which can kill the tumor safely and efficiently (j.am.chem.soc., 2017, 139, 1275-1284); the non-toxic amorphous iron nanoparticles were synthesized innovatively After entering the tumor, the nanoparticles released divalent iron ions in the weak acid environment of the tumor, catalyzed the overexpression of hydrogen peroxide in the tumor, and produced active oxygen components in situ, which also achieved the goal of safe and efficient killing of the tumor (angel Chem Int ed., 2016, 55, 2101-2106) ▲ this review summarizes the in situ chemical reactions in the internal tumor microenvironment or external trigger cell and tumor tissue microenvironment, and its multiple applications in cancer treatment In this review, the authors summarize the latest progress in the design and synthesis of representative nano diagnosis and treatment platforms, including the design of unique structures, structures, physical and chemical properties, and the practical application of multifunctional catalytic chemical reactions (mainly triggered by endogenous tumor microenvironment or exogenous physical irradiation) for cancer treatment Biological behavior At the same time, the possible challenges and development of this new cancer diagnosis model in the future are discussed in detail to provide as much help as possible for the development of this research field Part of the content is excerpted from the relevant research reports of Shi Jianlin and Chen Yu research team of Shanghai Silicate Research Institute of Chinese Academy of Sciences In this review, the authors focused on the latest progress in the research field of nano catalysis medicine, focusing on the new research direction of cancer diagnosis and treatment through catalysis / triggering of tumor tissue or in situ chemical reactions in cancer cells through nano platform It mainly includes tumor starvation therapy, chemokinetic therapy, gas therapy, Cancer Hypoxia alleviation, tumor microenvironment response diagnostic imaging and stimulation response drug release, as well as therapeutic agents triggered by other external stimuli The specific summary is shown in the figure below: ▲ the latest research progress and future development of nano particle enhanced catalytic chemical reaction in cancer treatment Personal profile: in 2012, he received his Ph.D from Shanghai Institute of silicate, Chinese Academy of Sciences Selected into the 100 person plan of Shanghai Institute of silicate, Chinese Academy of Sciences, and won the "national key research and development program for young scientists", "the first batch of outstanding young scientists of Chinese Academy of Sciences", "Shanghai Youth Science and technology star (a "Top young talents in Shanghai", "the first batch of China Association for science and technology young talents trust project", "Shanghai talent development fund plan", "Lu Jiaxi young talents award of Chinese Academy of Sciences" and other talents and fund support First or corresponding author: Nat Commun., chem SOC Rev (2), acc chem Res., adv mater (12), J am Chem SOC (4), angel Chem Int ed., nano letters, adv funct Mater (3), ACS Nano (5), nano today, chem, 75 papers were published in academic journals such as biomaterials (10), 33 papers with impact factor (if) greater than 10 were cited more than 7100 times, and h-index was 43 Main research fields: Based on the controllable preparation, biological effect and application in biomedicine of biomedical micro / nano functional materials, a series of new preparation methods have been developed to obtain a series of biomaterial systems with important clinical application prospects, and a variety of efficient new diagnosis and treatment methods, new technologies and new models have been developed in the fields of tumor, cardiovascular and cerebrovascular diseases, tissue engineering and other major diseases 。 Shi Jianlin, researcher and doctoral supervisor of Shanghai Silicate Research Institute, Chinese Academy of Sciences, the first batch of "hundred talents plan" candidates of Chinese Academy of Sciences (1994), winner of National Science Fund for Distinguished Young Scholars (1996), distinguished professor of Yangtze River scholars of the Ministry of Education (2008), personal profile: graduated from Nanjing University of technology in 1983; obtained doctoral degree from Shanghai Silicate Research Institute in 1989; 1989~ 1992, assistant researcher, Shanghai Silicate Research Institute, Chinese Academy of Sciences; 1993 ~ 1994, visiting scholar, Mapu Metal Institute, Stuttgart, Germany; 1994 ~ present, researcher, Shanghai Silicate Research Institute, Chinese Academy of Sciences He used to be director of Shanghai Silicate Research Institute of Chinese Academy of Sciences and director of State Key Laboratory of high performance ceramics and ultrastructure Main research fields: He has been engaged in the research of advanced ceramic material preparation science, sintering theory, high temperature reliability evaluation of structural ceramics and transparent ceramics (1983-2005) Now he is mainly engaged in the synthesis of inorganic nano materials, mesoporous materials and mesoporous host guest composite materials, heterogeneous catalytic performance, controllable synthesis and biocompatibility of mesoporous nano particles, multi-functional, drug transport and nano therapeutic agents, etc (1989 to present) More than 450 academic papers have been published and cited more than 24000 times, with H factor of 84 (2017) He has presided over more than 30 national, provincial and ministerial projects and won awards from many countries and provinces