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Cheng Zhukuan's research group has made new progress in improving the frequency of recombination

 Last Update: 2021-08-14
 Source: Internet
 Author: User

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crispr base editing

dna

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Meiosis is a core biological event in sexual reproduction species.

The Cheng Zhukuan research group of the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences used CRISPR/Cas9 gene editing technology to edit the single-stranded DNA binding protein RPA1a (Replication protein A large subunit) in rice , and obtained rpa1a mutant plants

The paper in 2021 Nian 8 Yue 7 date of publication online in Plant Physiology , Cheng Zhu wide-doctoral research group for the first author Yongjie Miao, Cheng Shen Yi Zhu wide research assistant and researcher for the co-corresponding author

Figure: Mutant RPA1a significantly increases the crossover frequency of homologous chromosomes

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