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    Home > Biochemistry News > Biotechnology News >  Chengdu Institute of Biology developed a new method for 2D-1D-2D mass spectrometry imaging

     Chengdu Institute of Biology developed a new method for 2D-1D-2D mass spectrometry imaging

    • Last Update: 2022-02-17
    • Source: Internet
    • Author: User
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     The chemical components in biological tissues contain important information on the occurrence and development of biological physiology and pathology.
    Obtaining these chemical information is of great significance to life science research

    Mass spectrometry imaging technology can obtain the spatial distribution information of target compounds without labeling.
    It has the characteristics of high sensitivity, accuracy and reliability, and fast analysis speed.
    It has been widely used in biological tissue analysis

    The existing mass spectrometry imaging methods need to slice the sample and fix it on a two-dimensional platform, and then scan and image the sample on the two-dimensional platform back and forth, so the imaging size is greatly limited by the size of the platform and the mass spectrometer interface

    Therefore, it is of great significance to develop mass spectrometry imaging techniques that can be flexibly applied to large-volume biological tissues



     The team of researcher Zhou Yan of Chengdu Institute of Biology, Chinese Academy of Sciences has successfully developed a 2D-1D-2D mass spectrometry imaging technology based on line sampling mass spectrometry, which can be used for imaging analysis of large-scale and uneven biological samples
    The technical principle is: firstly wrap the wire tightly into a two-dimensional plane (
    2D ), then imprint the biological sample on the wire plane, then unravel the two-dimensional wire plane into a one-dimensional wire ( 1D ), and then unpack the solution.
    The open line is transmitted to the developed ionization interface for ionization and mass spectrometry analysis, and finally the obtained data is restored to a two-dimensional image (
    2D ) through data processing such as branching and alignment
    This mass spectrometry imaging technology is no longer limited by platform size and mass spectrometry interface, and provides the possibility for spatial imaging analysis of large-volume biological samples

    At the same time, it also has the advantages of molecular imprinting technology, which can perform mass spectrometry imaging analysis on uneven biological samples

    As a technical demonstration, we used this technique to successfully realize mass spectrometry imaging of paper mulberry seedlings, and obtained spatial distribution information of various physiologically significant paper mulberry metabolites in different parts of seedlings

    This technology breaks through the size limitation of the existing mass spectrometry imaging technology, and is expected to be further applied in the fields of plant research and natural product analysis

    The research results are published in
    Analytical Chemistry ( https://pubs.
    ) in the form of a paper
    The first author of the paper is doctoral student Wang Yu, and the corresponding authors are researcher Zhou Yan and associate researcher Xia Bing of Chengdu Institute of Biology

    This research was supported by the National Natural Science Foundation of China (
    21772193 ) and the Scientific Research Equipment Development Project of the Chinese Academy of Sciences (YJKYYQ20170001 ) and the Chinese Academy of Sciences Youth Promotion Association Project ( 2019316 )


    2D-1D-2D Mass Spectrometry Imaging




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