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Myeloid cell tumors account for 15%-20% of brain tumors in children, and current treatments are surgical removal, radiotherapy and intensive chemotherapy.
in a recent study on the disease, scientists from the University of Newcastle achieved personalized treatment of patients by identifying the chromosomal characteristics of a group of children, significantly improving their survival.
results also show that many young people with myelin cell tumors avoid unnecessary chemotherapy and radiotherapy, thus avoiding unnecessary side effects.
results published in the journal "Prognostic Effect of whole-whole chromosomal aberration synced sin standard-risk, non-WNT/non-sH medulloblastoma: a retrospective, molecular analysis of the HIT-SIOP PNET 4 trial". Professor Steve Clifford, director of the Northern Cancer Institute at the University of Newcastle,
led the European study with Dr Edward Schwalbe of the University of Northumbria. Professor
Clifford said: "Our findings provide a new blueprint for personalized treatment of myelin, so that children can avoid receiving the same intensity of treatment.
studies have shown that low-risk patients may receive milder treatments designed to reduce toxicity and side effects, while high-risk patients require more in-depth treatment.
" The study found a chromosomal feature that divided children with cancer into two clinical groups by analyzing samples of 338 patients aged 4-21 aged 4-21 in 120 treatment facilities in seven European countries and found a chromosomal feature that divided children with cancer into two clinical groups - half of them low risk and survival rates of nearly 100 percent. Dr Edward Schwalbe, one of the
authors and a senior lecturer in bioinformatics and biostatistics at the University of Northumbria, said: "In this study, we found an easy-to-test chromosomal feature that predicts good outcomes in children with myelin.
myelin cell tumor is the most common malignant brain tumor in children, and it is important to improve the prognosis for patients with the disease.
"By deepening our understanding of brain tumours, we want to improve the cure rate, and most crucially, for those who survive, we want to ensure that they have a good quality of life after treatment."
," Added Clifford. looking ahead
, the authors hope that children with this characteristic in tumors will receive less aggressive treatment, reducing the lifelong side effects of treatment while maintaining a cure.
Source: Biological Exploration.